Structure of PDB 1rie Chain A Binding Site BS01

Receptor Information

>1rie Chain A (length=127) Species: 9913 (Bos taurus)

AMSKIEIKLSDIPEGKNMAFKWRGKPLFVRHRTKKEIDQEAAVEVSQLRD
PQHDLERVKKPEWVILIGVCTHLGCVPIANAGDFGGYYCPCHGSHYDASG
RIRKGPAPLNLEVPSYEFTSDDMVIVG

Ligand information

• Ligand ID: FES
• InChI: InChI=1S/2Fe.2S
• InChIKey: NIXDOXVAJZFRNF-UHFFFAOYSA-N
• SMILES:
  ACDLabs 10.04: [Fe]1S[Fe]S1
  CACTVS 3.341
  OpenEye OEToolkits 1.5.0: S1[Fe]S[Fe]1
• Formula: Fe2 S2
• Name: FE2/S2 (INORGANIC) CLUSTER
• PDB chain: 1rie Chain A Residue 200

Receptor-Ligand Complex Structure

Structure summary

• PDB: 1rie Structure of a water soluble fragment of the 'Rieske' iron-sulfur protein of the bovine heart mitochondrial cytochrome bc1 complex determined by MAD phasing at 1.5 A resolution.
• Resolution: 1.5 Å
• Binding residue (original residue number in PDB): C139 H141 L142 C144 C158 C160 H161 S163
• Binding residue (residue number reindexed from 1): C70 H72 L73 C75 C89 C91 H92 S94
• Annotation score: 1

Enzymatic activity

• Catalytic site (original residue number in PDB): H161
• Catalytic site (residue number reindexed from 1): H92
• Enzyme Commision number: 7.1.1.8: quinol--cytochrome-c reductase.

Gene Ontology

Molecular Function

• GO:0008121 ubiquinol-cytochrome-c reductase activity
• GO:0051537 2 iron, 2 sulfur cluster binding

Cellular Component

• GO:0016020 membrane

External links

• PDB: RCSB:1rie, PDBe:1rie, PDBj:1rie
• PDBsum: 1rie
• PubMed: 8736555
• UniProt: P13272|UCRI_BOVIN Cytochrome b-c1 complex subunit Rieske, mitochondrial (Gene Name=UQCRFS1)