Structure of PDB 1rhk Chain A Binding Site BS01

Receptor Information
>1rhk Chain A (length=140) Species: 9606 (Homo sapiens) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
DNSYKMDYPEMGLCIIINNKNFHKSTGMTSRSGTDVDAANLRETFRNLKY
EVRNKNDLTREEIVELMRDVSKEDHSKRSSFVCVLLSHGEEGIIFGTNGP
VDLKKITNFFRGDRCRSLTGKPKLFIIQACRGTELDCGIE
Ligand information
Receptor-Ligand Complex Structure
Global viewLocal viewStructure summary

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PDB1rhk Reducing the Peptidyl Features of Caspase-3 Inhibitors: A Structural Analysis.
Resolution2.5 Å
Binding residue
(original residue number in PDB)		R179 H237 G238 E239 C285
Binding residue
(residue number reindexed from 1)		R31 H88 G89 E90 C130
Enzymatic activity
Catalytic site (original residue number in PDB) T177 S178 H237 G238 C285 R286
Catalytic site (residue number reindexed from 1) T29 S30 H88 G89 C130 R131
Enzyme Commision number 3.4.22.56: caspase-3.
Gene Ontology
Molecular Function
GO:0004197 cysteine-type endopeptidase activity
GO:0008234 cysteine-type peptidase activity
Biological Process
GO:0006508 proteolysis

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Molecular Function
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Biological Process
External links
PDB RCSB:1rhk, PDBe:1rhk, PDBj:1rhk
PDBsum1rhk
PubMed15115390
UniProtP42574|CASP3_HUMAN Caspase-3 (Gene Name=CASP3)

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