Structure of PDB 1rh0 Chain A Binding Site BS01

Receptor Information

>1rh0 Chain A (length=425) Species: 9606 (Homo sapiens) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]

NPFQFYLTRVSGVKPKYNSGALHIKDILSPLFGTLVSSAQFNYCFDVDWL
VKQYPPEFRKKPILLVHGDKREAKAHLHAQAKPYENISLCQAKLDIAFGT
HHTKMMLLLYEEGLRVVIHTSNLIHADWHQKTQGIWLSPLYPRIADGTHK
SGESPTHFKANLISYLTAYNAPSLKEWIDVIHKHDLSETNVYLIGSTPGR
FQGSQKDNWGHFRLKKLLKDHASSMSWPVVGQFSSVGSLGADESKWLCSE
FKESMLTLGVPLYLIYPSVENVRTSLEGYPAGGSLPYSIQTAEKQNWLHS
YFHKWSAETSGRSNAMPHIKTYMRPSPDFSKIAWFLVTSANLSKAAWGAL
EKNGTQLMIRSYELGVLFLPSALGLDSFKVKQKFATFPVPYDLPPELYGS
KDRPWIWNIPYVKAPDTHGNMWVPS

Ligand information

>1rh0 Chain D (length=2) [Search DNA sequence] [Download ligand structure] [Download structure with residue number starting from 1] [View ligand structure]

Receptor-Ligand Complex Structure

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Structure summary

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PDB	1rh0 Explorations of peptide and oligonucleotide binding sites of tyrosyl-DNA phosphodiesterase using vanadate complexes.
Resolution	2.3 Å
Binding residue (original residue number in PDB)	Y204 F259 H263 S403 P461 S518 K519 A520
Binding residue (residue number reindexed from 1)	Y43 F98 H102 S238 P286 S343 K344 A345

Enzymatic activity

Enzyme Commision number

3.1.4.-

Gene Ontology

	Molecular Function
GO:0008081	phosphoric diester hydrolase activity

	Biological Process
GO:0006281	DNA repair

	Cellular Component
GO:0005634	nucleus

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Cellular Component

External links

PDB	RCSB:1rh0, PDBe:1rh0, PDBj:1rh0
PDBsum	1rh0
PubMed	14761185
UniProt	Q9NUW8\|TYDP1_HUMAN Tyrosyl-DNA phosphodiesterase 1 (Gene Name=TDP1)

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