Structure of PDB 1rf8 Chain A Binding Site BS01

Receptor Information
>1rf8 Chain A (length=213) Species: 4932 (Saccharomyces cerevisiae) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
MSVEEVSKKFEENVSVDDTTATPKTVLSDSAHFDVKHPLNTKWTLWYTKP
AVDKSESWSDLLRPVTSFQTVEEFWAIIQNIPEPHELPLKSDYHVFRNDV
RPEWEDEANAKGGKWSFQLCGKGADIDELWLCTLLAVIGETIDEDDSQIN
GVVLSIRKGGNKFALWTKCEDKEPLLRIGGKFKQVLKLTDDGHLEFFPHC
SANGRHPQPSITL
Ligand information
Ligand IDMTN
InChIInChI=1S/C10H19NO3S2/c1-9(2)6-8(7-15-16(5,13)14)10(3,4)11(9)12/h6,12H,7H2,1-5H3
InChIKeyMXZPGYFBZHBAQM-UHFFFAOYSA-N
SMILES
SoftwareSMILES
CACTVS 3.370CC1(C)C=C(CS[S](C)(=O)=O)C(C)(C)N1[O]
OpenEye OEToolkits 1.7.2CC1(C=C(C(N1[O])(C)C)CSS(=O)(=O)C)C
ACDLabs 12.01ON1C(C=C(CSS(=O)(=O)C)C1(C)C)(C)C
FormulaC10 H18 N O3 S2
NameS-[(1-oxyl-2,2,5,5-tetramethyl-2,5-dihydro-1H-pyrrol-3-yl)methyl] methanesulfonothioate;
MTSL
ChEMBL
DrugBankDB08217
ZINCZINC000002569540
PDB chain1rf8 Chain A Residue 321 [Download ligand structure] [Download structure with residue number starting from 1] [View ligand structure]
Receptor-Ligand Complex Structure
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PDB1rf8 Ribosome loading onto the mRNA cap is driven by conformational coupling between eIF4G and eIF4E.
ResolutionN/A
Binding residue
(original residue number in PDB)		E128 C132
Binding residue
(residue number reindexed from 1)		E128 C132
Annotation score1
Enzymatic activity
Enzyme Commision number ?
Gene Ontology
Molecular Function
GO:0000340 RNA 7-methylguanosine cap binding
GO:0003723 RNA binding
GO:0003743 translation initiation factor activity
GO:0005515 protein binding
GO:0032266 phosphatidylinositol-3-phosphate binding
GO:0098808 mRNA cap binding
Biological Process
GO:0000184 nuclear-transcribed mRNA catabolic process, nonsense-mediated decay
GO:0006412 translation
GO:0006413 translational initiation
GO:0006417 regulation of translation
GO:0006446 regulation of translational initiation
GO:0051726 regulation of cell cycle
GO:1901195 positive regulation of formation of translation preinitiation complex
Cellular Component
GO:0005634 nucleus
GO:0005737 cytoplasm
GO:0005840 ribosome
GO:0010494 cytoplasmic stress granule
GO:0016281 eukaryotic translation initiation factor 4F complex

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Molecular Function
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Biological Process
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Cellular Component
External links
PDB RCSB:1rf8, PDBe:1rf8, PDBj:1rf8
PDBsum1rf8
PubMed14675538
UniProtP07260|IF4E_YEAST Eukaryotic translation initiation factor 4E (Gene Name=CDC33)

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