Structure of PDB 1r49 Chain A Binding Site BS01

Receptor Information
>1r49 Chain A (length=548) Species: 9606 (Homo sapiens) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
KWKWWEEERYPEGIKWKFLEHKGPVFAPPYEPLPENVKFYYDGKVMKLSP
KAEEVATFFAKMLDHEYTTKEIFRKNFFKDWRKEMTNEEKNIITNLSKCD
FTQMSQYFKAQTEARKQMSKEEKLKIKEENEKLLKEYGFCIMDNHKERIA
NFKIEPPGLFRGRGNHPKMGMLKRRIMPEDIIINCSDAKVPSPPPGHKWK
EVRHDNKVTWLVSWTENIQGSIKYIMLNPSSRIKGEKDWQKYETARRLKK
CVDKIRNQYREDWKSKEMKVRQRAVALYFIDKLALRAGNEKEEGETADTV
GCCSLRVEHINLHPELDGQEYVVEFDFLGRDSIRYYNKVPVEKRVFKNLQ
LFMENKQPEDDLFDRLNTGILNKHLQDLMEGLTAKVFRTYNASITLQQQL
KELTAPDENIPAKILSYNRANRAVAILCNHQMMNLQTKIDAKKEQLADAR
RDLKSAKADAKVMKDAKTKKVVESKKKAVQRLEEQLMKLEVQATDREENK
QSKLNFLDPRITVAWCKKWGVPIEKIYNKTQREKFAWAIDMADEDYEF
Ligand information
Receptor-Ligand Complex Structure
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PDB1r49 The role of lysine 532 in the catalytic mechanism of human topoisomerase I.
Resolution3.13 Å
Binding residue
(original residue number in PDB)		H266 R364 V410 T411 W412 Y426 M428 K439 K443 R532 D533 K587 K650 N722 F723
Binding residue
(residue number reindexed from 1)		H65 R163 V208 T209 W210 Y224 M226 K237 K241 R330 D331 K385 K438 N505 F506
Enzymatic activity
Enzyme Commision number 5.6.2.1: DNA topoisomerase.
Gene Ontology
Molecular Function
GO:0003677 DNA binding
GO:0003917 DNA topoisomerase type I (single strand cut, ATP-independent) activity
Biological Process
GO:0006265 DNA topological change
Cellular Component
GO:0005694 chromosome

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Molecular Function
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Biological Process
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Cellular Component
External links
PDB RCSB:1r49, PDBe:1r49, PDBj:1r49
PDBsum1r49
PubMed14594810
UniProtP11387|TOP1_HUMAN DNA topoisomerase 1 (Gene Name=TOP1)

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