Structure of PDB 1r0z Chain A Binding Site BS01

Receptor Information
>1r0z Chain A (length=275) Species: 10090 (Mus musculus) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
TGIIMENVTAFWEEGFGELLEKVQKHSSDENNVSFSHLCLVGNPVLKNIN
LNIEKGEMLAITGSTGSGKTSLLMLILGELEASEGIIKHSGRVSFCSQFS
WIMPGTIKENIIFGVSYDEYRYKSVVKACQLQQDITKFAEQDNTVLGEGG
VTLSGGQRARISLARAVYKDADLYLLDSPFGYLDVFTEEQVFESCVCKLM
ANKTRILVTSKMEHLRKADKILILHQGSSYFYGTFSELQSLRPDFSSKLM
GYDTFDQFTEERRSSILTETLRRFS
Ligand information
Ligand IDMG
InChIInChI=1S/Mg/q+2
InChIKeyJLVVSXFLKOJNIY-UHFFFAOYSA-N
SMILES
SoftwareSMILES
ACDLabs 10.04
OpenEye OEToolkits 1.5.0		[Mg+2]
CACTVS 3.341[Mg++]
FormulaMg
NameMAGNESIUM ION
ChEMBL
DrugBankDB01378
ZINC
PDB chain1r0z Chain A Residue 674 [Download ligand structure] [Download structure with residue number starting from 1] [View ligand structure]
Receptor-Ligand Complex Structure
Global viewLocal viewStructure summary

[Spin on] [Spin off] [Reset]
[High quality] [Low quality]
[White background] [Black background]
[Spin on] [Spin off] [Reset]
[High quality] [Low quality]
[White background] [Black background]
PDB1r0z Structure of nucleotide-binding domain 1 of the cystic fibrosis transmembrane conductance regulator.
Resolution2.35 Å
Binding residue
(original residue number in PDB)		T465 Q493 D572
Binding residue
(residue number reindexed from 1)		T70 Q98 D177
Annotation score1
Enzymatic activity
Enzyme Commision number 5.6.1.6: channel-conductance-controlling ATPase.
Gene Ontology
Molecular Function
GO:0005524 ATP binding
GO:0016887 ATP hydrolysis activity

View graph for
Molecular Function
External links
PDB RCSB:1r0z, PDBe:1r0z, PDBj:1r0z
PDBsum1r0z
PubMed14685259
UniProtP26361|CFTR_MOUSE Cystic fibrosis transmembrane conductance regulator (Gene Name=Cftr)

[Back to BioLiP]