Structure of PDB 1qtn Chain A Binding Site BS01

Receptor Information
>1qtn Chain A (length=152) Species: 9606 (Homo sapiens) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
DKVYQMKSKPRGYCLIINNHNFAKAREKVPKLHSIRDRNGTHLDAGALTT
TFEELHFEIKPHDDCTVEQIYEILKIYQLMDHSNMDCFICCILSHGDKGI
IYGTDGQEAPIYELTSQFTGLKCPSLAGKPKVFFIQACQGDNYQKGIPVE
TD
Ligand information
Receptor-Ligand Complex Structure
Global viewLocal viewStructure summary

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PDB1qtn The atomic-resolution structure of human caspase-8, a key activator of apoptosis.
Resolution1.2 Å
Binding residue
(original residue number in PDB)		R260 H317 C360
Binding residue
(residue number reindexed from 1)		R38 H95 C138
Enzymatic activity
Catalytic site (original residue number in PDB) R258 D259 H317 G318 C360 Q361
Catalytic site (residue number reindexed from 1) R36 D37 H95 G96 C138 Q139
Enzyme Commision number 3.4.22.61: caspase-8.
Gene Ontology
Molecular Function
GO:0004197 cysteine-type endopeptidase activity
GO:0008234 cysteine-type peptidase activity
Biological Process
GO:0006508 proteolysis

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Molecular Function
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Biological Process
External links
PDB RCSB:1qtn, PDBe:1qtn, PDBj:1qtn
PDBsum1qtn
PubMed10508785
UniProtQ14790|CASP8_HUMAN Caspase-8 (Gene Name=CASP8)

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