Structure of PDB 1qsy Chain A Binding Site BS01

Receptor Information
>1qsy Chain A (length=539) Species: 271 (Thermus aquaticus) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
ALEEAPWPPPEGAFVGFVLSRKEPMWADLLALAAARGGRVHRAPEPYKAL
RDLKEERGLLAKDLSVLALREGLGLPPGDDPMLLAYLLDPSNTTPEGVAR
RYGGEWTEEAGERAALSERLFANLWGRLEGEERLLWLYREVERPLSAVLA
HMEATGVRLDVAYLRALSLEVAEEIARLEAEVFRLAGHPFNLNSRDQLER
VLFDELGLPAIGKTEKTGKRSTSAAVLEALREAHPIVEKILQYRELTKLK
STYIDPLPDLIHPRTGRLHTRFNQTATATGRLSSSDPNLQNIPVRTPLGQ
RIRRAFIAEEGWLLVALDYSQIELRVLAHLSGDENLIRVFQEGRDIHTET
ASWMFGVPREAVDPLMRRAAKTINFGVLYGMSAHRLSQELAIPYEEAQAF
IERYFQSFPKVRAWIEKTLEEGRRRGYVETLFGRRRYVPDLEARVKSVRE
AAERMAFNMPVQGTAADLMKLAMVKLFPRLEEMGARMLLQVHDELVLEAP
KERAEAVARLAKEVMEGVYPLAVPLEVEVGIGEDWLSAK
Ligand information
Receptor-Ligand Complex Structure
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PDB1qsy Structure-based design of Taq DNA polymerases with improved properties of dideoxynucleotide incorporation.
Resolution2.3 Å
Binding residue
(original residue number in PDB)		R487 T506 K508 T509 S513 T514 A516 R536 K540 Y545 R573 Q582 N583 I584 P585 V586 R587 R660 V783 H784
Binding residue
(residue number reindexed from 1)		R195 T214 K216 T217 S221 T222 A224 R244 K248 Y253 R281 Q290 N291 I292 P293 V294 R295 R368 V491 H492
Enzymatic activity
Enzyme Commision number 2.7.7.7: DNA-directed DNA polymerase.
Gene Ontology
Molecular Function
GO:0001882 nucleoside binding
GO:0003676 nucleic acid binding
GO:0003677 DNA binding
GO:0003887 DNA-directed DNA polymerase activity
Biological Process
GO:0006260 DNA replication
GO:0006261 DNA-templated DNA replication
GO:0006281 DNA repair

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Molecular Function
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Biological Process
External links
PDB RCSB:1qsy, PDBe:1qsy, PDBj:1qsy
PDBsum1qsy
PubMed10449720
UniProtP19821|DPO1_THEAQ DNA polymerase I, thermostable (Gene Name=polA)

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