Structure of PDB 1qr1 Chain A Binding Site BS01
Receptor Information
>1qr1 Chain A (length=275) Species:
9606
(Homo sapiens) [
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GSHSMRYFFTSVSRPGRGEPRFIAVGYVDDTQFVRFDSDAASQRMEPRAP
WIEQEGPEYWDGETRKVKAHSQTHRVDLGTLRGYYNQSEAGSHTVQRMYG
CDVGSDWRFLRGYHQYAYDGKDYIALKEDLRSWTAADMAAQTTKHKWEAA
HVAEQLRAYLEGTCVEWLRRYLENGKETLQRTDAPKTHMTHHAVSDHEAT
LRCWALSFYPAEITLTWQRDGEDQTQDTELVETRPAGDGTFQKWAAVVVP
SGQEQRYTCHVQHEGLPKPLTLRWE
Ligand information
>1qr1 Chain C (length=9) Species:
9606
(Homo sapiens) [
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IISAVVGIL
Receptor-Ligand Complex Structure
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PDB
1qr1
Poor binding of a HER-2/neu epitope (GP2) to HLA-A2.1 is due to a lack of interactions with the center of the peptide.
Resolution
2.4 Å
Binding residue
(original residue number in PDB)
Y7 E63 H70 T73 D77 L81 Y84 Y99 Y116 T143 W147 Q155 Y159 W167 Y171
Binding residue
(residue number reindexed from 1)
Y7 E63 H70 T73 D77 L81 Y84 Y99 Y116 T143 W147 Q155 Y159 W167 Y171
Enzymatic activity
Enzyme Commision number
?
External links
PDB
RCSB:1qr1
,
PDBe:1qr1
,
PDBj:1qr1
PDBsum
1qr1
PubMed
10593938
UniProt
P04439
|HLAA_HUMAN HLA class I histocompatibility antigen, A alpha chain (Gene Name=HLA-A)
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