Structure of PDB 1qjb Chain A Binding Site BS01
Receptor Information
>1qjb Chain A (length=228) Species:
9606
(Homo sapiens) [
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MDKNELVQKAKLAEQAERYDDMAACMKSVTEQGAELSNEERNLLSVAYKN
VVGARRSSWRVVSSIEQKEKKQQMAREYREKIETELRDICNDVLSLLEKF
LIPNASQAESKVFYLKMKGDYYRYLAEVAAGDDKKGIVDQSQQAYQEAFE
ISKKEMQPTHPIRLGLALNFSVFYYEILNSPEKACSLAKTAFDEAIAELD
TLSEESYKDSTLIMQLLRDNLTLWTSDT
Ligand information
>1qjb Chain Q (length=8) Species:
9606
(Homo sapiens) [
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ARSHSYPA
Receptor-Ligand Complex Structure
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PDB
1qjb
Structural Analysis of 14-3-3 Phosphopeptide Complexes Identifies a Dual Role for the Nuclear Export Signal of 14-3-3 in Ligand Binding
Resolution
2.0 Å
Binding residue
(original residue number in PDB)
K49 R56 K120 R127 Y128 L172 N173 V176 E180 I217 N224 L227 W228
Binding residue
(residue number reindexed from 1)
K49 R56 K116 R123 Y124 L168 N169 V172 E176 I213 N220 L223 W224
Enzymatic activity
Enzyme Commision number
?
Gene Ontology
Molecular Function
GO:0003723
RNA binding
GO:0005515
protein binding
GO:0019901
protein kinase binding
GO:0019904
protein domain specific binding
GO:0031625
ubiquitin protein ligase binding
GO:0042802
identical protein binding
GO:0044325
transmembrane transporter binding
GO:0045296
cadherin binding
GO:0050815
phosphoserine residue binding
GO:0140297
DNA-binding transcription factor binding
GO:0140311
protein sequestering activity
Biological Process
GO:0000122
negative regulation of transcription by RNA polymerase II
GO:0001525
angiogenesis
GO:0003016
respiratory system process
GO:0006468
protein phosphorylation
GO:0006605
protein targeting
GO:0007165
signal transduction
GO:0008039
synaptic target recognition
GO:0008104
protein localization
GO:0030324
lung development
GO:0031647
regulation of protein stability
GO:0035148
tube formation
GO:0042149
cellular response to glucose starvation
GO:0043066
negative regulation of apoptotic process
GO:0043067
regulation of programmed cell death
GO:0045824
negative regulation of innate immune response
GO:0051683
establishment of Golgi localization
GO:0070371
ERK1 and ERK2 cascade
GO:0070372
regulation of ERK1 and ERK2 cascade
GO:0090128
regulation of synapse maturation
GO:0090168
Golgi reassembly
GO:1900181
negative regulation of protein localization to nucleus
GO:1904262
negative regulation of TORC1 signaling
Cellular Component
GO:0005615
extracellular space
GO:0005634
nucleus
GO:0005654
nucleoplasm
GO:0005737
cytoplasm
GO:0005829
cytosol
GO:0005925
focal adhesion
GO:0031982
vesicle
GO:0042470
melanosome
GO:0070062
extracellular exosome
GO:0072562
blood microparticle
GO:0098686
hippocampal mossy fiber to CA3 synapse
GO:0098978
glutamatergic synapse
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Molecular Function
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Biological Process
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Cellular Component
External links
PDB
RCSB:1qjb
,
PDBe:1qjb
,
PDBj:1qjb
PDBsum
1qjb
PubMed
10488331
UniProt
P63104
|1433Z_HUMAN 14-3-3 protein zeta/delta (Gene Name=YWHAZ)
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