Structure of PDB 1qgr Chain A Binding Site BS01

Receptor Information
>1qgr Chain A (length=871) Species: 9606 (Homo sapiens) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
MELITILEKTVSPDRLELEAAQKFLERAAVENLPTFLVELSRVLANPGNS
QVARVAAGLQIKNSLTSKDPDIKAQYQQRWLAIDANARREVKNYVLHTLG
TETYRPSSASQCVAGIACAEIPVNQWPELIPQLVANVTNPNSTEHMKEST
LEAIGYICQDIDPEQLQDKSNEILTAIIQGMRKEEPSNNVKLAATNALLN
SLEFTKANFDKESERHFIMQVVCEATQCPDTRVRVAALQNLVKIMSLYYQ
YMETYMGPALFAITIEAMKSDIDEVALQGIEFWSNVCDEEMDLAIEASEA
AEQGRPPEHTSKFYAKGALQYLVPILTQTLTKQDENDDDDDWNPCKAAGV
CLMLLATCCEDDIVPHVLPFIKEHIKNPDWRYRDAAVMAFGCILEGPEPS
QLKPLVIQAMPTLIELMKDPSVVVRDTAAWTVGRICELLPEAAINDVYLA
PLLQCLIEGLSAEPRVASNVCWAFSSLAEAAYEAADVADDQEEPATYCLS
SSFELIVQKLLETTDRPDGHQNNLRSSAYESLMEIVKNSAKDCYPAVQKT
TLVIMERLQQVLQMESHIQSTSDRIQFNDLQSLLCATLQNVLRKVQHQDA
LQISDVVMASLLRMFSGGVQEDALMAVSTLVEVLGGEFLKYMEAFKPFLG
IGLKNYAEYQVCLAAVGLVGDLCRALQSNIIPFCDEVMQLLLENLGNENV
HRSVKPQILSVFGDIALAIGGEFKKYLEVVLNTLQQASQAQVDKSDYDMV
DYLNELRESCLEAYTGIVQGLKGDQENVHPDVMLVQPRVEFILSFIDHIA
GDEDHTDGVVACAAGLIGDLCTAFGKDVLKLVEARPMIHELLTEGRRSKT
NKAKTLARWATKELRKLKNQA
Ligand information
>1qgr Chain B (length=24) Species: 9606 (Homo sapiens) [Search peptide sequence] [Download ligand structure] [Download structure with residue number starting from 1] [View ligand structure]
RRRRIEVNVELRKAKKDDQMLKRR
Receptor-Ligand Complex Structure
Global viewLocal viewStructure summary

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PDB1qgr Structure of importin-beta bound to the IBB domain of importin-alpha.
Resolution2.3 Å
Binding residue
(original residue number in PDB)		E530 Q589 G623 E626 D627 M630 E637 Q665 G672 D676 R679 D719 E767 T770 Q774 G778 G820 D824 K857 L861 W864
Binding residue
(residue number reindexed from 1)		E530 Q589 G618 E621 D622 M625 E632 Q660 G667 D671 R674 D714 E762 T765 Q769 G773 G815 D819 K852 L856 W859
Enzymatic activity
Enzyme Commision number ?
Gene Ontology
Molecular Function
GO:0003723 RNA binding
GO:0005515 protein binding
GO:0008139 nuclear localization sequence binding
GO:0008270 zinc ion binding
GO:0019899 enzyme binding
GO:0019904 protein domain specific binding
GO:0031267 small GTPase binding
GO:0051879 Hsp90 protein binding
GO:0061608 nuclear import signal receptor activity
GO:0061676 importin-alpha family protein binding
Biological Process
GO:0006404 RNA import into nucleus
GO:0006606 protein import into nucleus
GO:0006607 NLS-bearing protein import into nucleus
GO:0006610 ribosomal protein import into nucleus
GO:0006886 intracellular protein transport
GO:0007079 mitotic chromosome movement towards spindle pole
GO:0007080 mitotic metaphase chromosome alignment
GO:0015031 protein transport
GO:0030953 astral microtubule organization
GO:0040001 establishment of mitotic spindle localization
GO:0090307 mitotic spindle assembly
Cellular Component
GO:0005576 extracellular region
GO:0005634 nucleus
GO:0005635 nuclear envelope
GO:0005643 nuclear pore
GO:0005654 nucleoplasm
GO:0005737 cytoplasm
GO:0005829 cytosol
GO:0010494 cytoplasmic stress granule
GO:0016020 membrane
GO:0031965 nuclear membrane
GO:0032991 protein-containing complex
GO:0035580 specific granule lumen
GO:0042564 NLS-dependent protein nuclear import complex
GO:0070062 extracellular exosome
GO:0071782 endoplasmic reticulum tubular network
GO:1904813 ficolin-1-rich granule lumen

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Molecular Function
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Biological Process
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Cellular Component
External links
PDB RCSB:1qgr, PDBe:1qgr, PDBj:1qgr
PDBsum1qgr
PubMed10353244
UniProtQ14974|IMB1_HUMAN Importin subunit beta-1 (Gene Name=KPNB1)

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