Structure of PDB 1qfn Chain A Binding Site BS01

Receptor Information

>1qfn Chain A (length=85) Species: 562 (Escherichia coli)

MQTVIFGRSGCPYSVRAKDLAEKLSNERDDFQYQYVDIRAEGITKEDLQQ
KAGKPVETVPQIFVDQQHIGGYTDFAAWVKENLDA

Ligand information

>1qfn Chain B (length=25) Species: 562 (Escherichia coli)

GAEDAQDDLVPSIQDDGSESGACKI

Receptor-Ligand Complex Structure

Structure summary

• PDB: 1qfn Binding specificity and mechanistic insight into glutaredoxin-catalyzed protein disulfide reduction.
• Resolution: N/A
• Binding residue (original residue number in PDB): C11 Y13 R16 R39 T44 K45 E46 T58 V59 P60 Y72 T73 A76 K80
• Binding residue (residue number reindexed from 1): C11 Y13 R16 R39 T44 K45 E46 T58 V59 P60 Y72 T73 A76 K80

Enzymatic activity

• Catalytic site (original residue number in PDB): R8 G10 C11 Y13 S14 K18 Y72
• Catalytic site (residue number reindexed from 1): R8 G10 C11 Y13 S14 K18 Y72

Gene Ontology

Molecular Function

• GO:0000166 nucleotide binding
• GO:0009055 electron transfer activity
• GO:0015035 protein-disulfide reductase activity
• GO:0015036 disulfide oxidoreductase activity
• GO:0015038 glutathione disulfide oxidoreductase activity
• GO:0019153 protein-disulfide reductase (glutathione) activity

Biological Process

• GO:0009263 deoxyribonucleotide biosynthetic process
• GO:0010134 sulfate assimilation via adenylyl sulfate reduction
• GO:0019345 cysteine biosynthetic process via S-sulfo-L-cysteine
• GO:0034599 cellular response to oxidative stress
• GO:0045454 cell redox homeostasis

Cellular Component

• GO:0005737 cytoplasm

External links

• PDB: RCSB:1qfn, PDBe:1qfn, PDBj:1qfn
• PDBsum: 1qfn
• PubMed: 10493864
• UniProt: P68688|GLRX1_ECOLI Glutaredoxin 1 (Gene Name=grxA)