Structure of PDB 1qdu Chain A Binding Site BS01

Receptor Information
>1qdu Chain A (length=153) Species: 9606 (Homo sapiens) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
LDKVYQMKSKPRGYCLIINNHNFAKAREKVPKLHSIRDRNGTHLDAGALT
TTFEELHFEIKPHHDCTVEQIYEILKIYQLMDHSNMDCFICCILSHGDKG
IIYGTDGQEAPIYELTSQFTGLKCPSLAGKPKVFFIQACQGDNYQKGIPV
ETD
Ligand information
Receptor-Ligand Complex Structure
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PDB1qdu The three-dimensional structure of caspase-8: an initiator enzyme in apoptosis.
Resolution2.8 Å
Binding residue
(original residue number in PDB)		R179 H237 C285
Binding residue
(residue number reindexed from 1)		R39 H96 C139
Enzymatic activity
Catalytic site (original residue number in PDB) R177 D178 H237 G238 C285 Q286
Catalytic site (residue number reindexed from 1) R37 D38 H96 G97 C139 Q140
Enzyme Commision number 3.4.22.61: caspase-8.
Gene Ontology
Molecular Function
GO:0004197 cysteine-type endopeptidase activity
GO:0008234 cysteine-type peptidase activity
Biological Process
GO:0006508 proteolysis

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Molecular Function
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Biological Process
External links
PDB RCSB:1qdu, PDBe:1qdu, PDBj:1qdu
PDBsum1qdu
PubMed10508784
UniProtQ14790|CASP8_HUMAN Caspase-8 (Gene Name=CASP8)

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