Structure of PDB 1q5p Chain A Binding Site BS01

Receptor Information

>1q5p Chain A (length=269) Species: 1467 (Lederbergia lenta)

AQSVPWGISRVQAPAAHNRGLTGSGVKVAVLDTGISTHPDLNIRGGASFV
PGEPSTQDGNGHGTHVAGTIAALDNSIGVLGVAPSAELYAVKVLGASGSG
AISSIAQGLEWAGNNGMHVANLSLGSPSPSATLEQAVNSATSRGVLVVAA
SGNEGAGSIDYPARYANAMAVGATDQNNNRASFSQYGAGLDIVAPGVNVQ
STYPGSTYASLNGTSMATPHVAGAAALVKQKNPSWSNVQIRNHLKNTATS
LGSTNLYGSGLVNAEAATR

Ligand information

• Ligand ID: CA
• InChI: InChI=1S/Ca/q+2
• InChIKey: BHPQYMZQTOCNFJ-UHFFFAOYSA-N
• SMILES:
  CACTVS 3.341: [Ca++]
  ACDLabs 10.04
  OpenEye OEToolkits 1.5.0: [Ca+2]
• Formula: Ca
• Name: CALCIUM ION
• DrugBank: DB14577
• PDB chain: 1q5p Chain A Residue 271

Receptor-Ligand Complex Structure

Structure summary

• PDB: 1q5p Do enzymes change the nature of transition states? Mapping the transition state for general acid-base catalysis of a serine protease
• Resolution: 1.6 Å
• Binding residue (original residue number in PDB): Q2 D40 L73 N75 I77 V79
• Binding residue (residue number reindexed from 1): Q2 D40 L73 N75 I77 V79
• Annotation score: 4

Enzymatic activity

• Catalytic site (original residue number in PDB): D32 H62 N153 S215
• Catalytic site (residue number reindexed from 1): D32 H62 N153 S215
• Enzyme Commision number: 3.4.21.62: subtilisin.

Gene Ontology

Molecular Function

• GO:0004252 serine-type endopeptidase activity
• GO:0008236 serine-type peptidase activity
• GO:0046872 metal ion binding

Biological Process

• GO:0006508 proteolysis
• GO:0030435 sporulation resulting in formation of a cellular spore

Cellular Component

• GO:0005576 extracellular region

External links

• PDB: RCSB:1q5p, PDBe:1q5p, PDBj:1q5p
• PDBsum: 1q5p
• PubMed: 12962477
• UniProt: P29600|SUBS_LEDLE Subtilisin Savinase