Structure of PDB 1q11 Chain A Binding Site BS01

Receptor Information
>1q11 Chain A (length=329) Species: 9606 (Homo sapiens) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
APSPEEKLHLITRNLQEVLGEEKLKEILKERELKIYWGTATTGKPHVAYF
VPMSKIADFLKAGCEVTILFADLHAYLDNMKAPWELLELRVSYYENVIKA
MLESIGVPLEKLKFIKGTDYQLSKEYTLDVYRLSSVVTQHDSKKAGAEVV
KQVEHPLLSGLLYPGLQALDEEYLKVDAQFGGIDQRKIFTFAEKYLPALG
YSKRVHLMNPMVPGLTGKIDLLDRKEDVKKKLKKAFCEPGNVENNGVLSF
IKHVLFPLKSEFVILRDEKWGGNKTYTAYVDLEKDFAAEVVHPGDLKNSV
EVALNKLLDPIREKFNTPALKKLASAAYP
Ligand information
Ligand IDTYE
InChIInChI=1S/C9H13NO2/c10-8(6-11)5-7-1-3-9(12)4-2-7/h1-4,8,11-12H,5-6,10H2/t8-/m0/s1
InChIKeyDBLDQZASZZMNSL-QMMMGPOBSA-N
SMILES
SoftwareSMILES
OpenEye OEToolkits 1.7.0c1cc(ccc1CC(CO)N)O
CACTVS 3.370N[CH](CO)Cc1ccc(O)cc1
ACDLabs 12.01Oc1ccc(cc1)CC(N)CO
CACTVS 3.370N[C@H](CO)Cc1ccc(O)cc1
OpenEye OEToolkits 1.7.0c1cc(ccc1C[C@@H](CO)N)O
FormulaC9 H13 N O2
Name4-[(2S)-2-amino-3-hydroxypropyl]phenol;
tyrosinol;
bound form of TYROSINAL
ChEMBL
DrugBank
ZINCZINC000000403178
PDB chain1q11 Chain A Residue 401 [Download ligand structure] [Download structure with residue number starting from 1] [View ligand structure]
Receptor-Ligand Complex Structure
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PDB1q11 Crystal structures that suggest late development of genetic code components for differentiating aromatic side chains
Resolution1.6 Å
Binding residue
(original residue number in PDB)		Y39 G41 L72 A74 H77 V152 Y166 Q170 D173 Q188
Binding residue
(residue number reindexed from 1)		Y36 G38 L69 A71 H74 V149 Y163 Q167 D170 Q185
Annotation score2
Enzymatic activity
Enzyme Commision number 6.1.1.1: tyrosine--tRNA ligase.
Gene Ontology
Molecular Function
GO:0000166 nucleotide binding
GO:0004812 aminoacyl-tRNA ligase activity
GO:0004831 tyrosine-tRNA ligase activity
GO:0005524 ATP binding
Biological Process
GO:0006418 tRNA aminoacylation for protein translation
GO:0006437 tyrosyl-tRNA aminoacylation

View graph for
Molecular Function
View graph for
Biological Process
External links
PDB RCSB:1q11, PDBe:1q11, PDBj:1q11
PDBsum1q11
PubMed14671330
UniProtP54577|SYYC_HUMAN Tyrosine--tRNA ligase, cytoplasmic (Gene Name=YARS1)

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