Structure of PDB 1q0p Chain A Binding Site BS01

Receptor Information
>1q0p Chain A (length=192) Species: 9606 (Homo sapiens) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
SMNIYLVLDGSDSIGASNFTGAKKSLVNLIEKVASYGVKPRYGLVTYATY
PKIWVKVSEADSSNADWVTKQLNEINYEDHKLKSGTNTKKALQAVYSMMS
WPDDVPPEGWNRTRHVIILMTDGLHNMGGDPITVIDEIRDLLYIGKDRKN
PREDYLDVYVFGVGPLVNQVNINALASKKDNEQHVFKVKDLS
Ligand information
Ligand IDMN
InChIInChI=1S/Mn/q+2
InChIKeyWAEMQWOKJMHJLA-UHFFFAOYSA-N
SMILES
SoftwareSMILES
ACDLabs 10.04
OpenEye OEToolkits 1.5.0		[Mn+2]
CACTVS 3.341[Mn++]
FormulaMn
NameMANGANESE (II) ION
ChEMBL
DrugBankDB06757
ZINC
PDB chain1q0p Chain A Residue 500 [Download ligand structure] [Download structure with residue number starting from 1] [View ligand structure]
Receptor-Ligand Complex Structure
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PDB1q0p Crystal Structure of the A Domain from Complement Factor B Reveals an Integrin-like Open Conformation.
Resolution1.8 Å
Binding residue
(original residue number in PDB)		S253 S255 T328
Binding residue
(residue number reindexed from 1)		S11 S13 T86
Annotation score4
Enzymatic activity
Enzyme Commision number 3.4.21.47: alternative-complement-pathway C3/C5 convertase.
Gene Ontology
Molecular Function
GO:0004252 serine-type endopeptidase activity
Biological Process
GO:0006956 complement activation
Cellular Component
GO:0005576 extracellular region

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Molecular Function
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Biological Process
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Cellular Component
External links
PDB RCSB:1q0p, PDBe:1q0p, PDBj:1q0p
PDBsum1q0p
PubMed15016353
UniProtP00751|CFAB_HUMAN Complement factor B (Gene Name=CFB)

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