Structure of PDB 1pzs Chain A Binding Site BS01

Receptor Information
>1pzs Chain A (length=171) Species: 1773 (Mycobacterium tuberculosis) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
QSLTSTLTAPDGTKVATAKFEFANGYATVTIATTGVGKLTPGFHGLHIHQ
VGKCEPNSVAPTGGAPGNFLSAGGHYHVPGHTGTPASGDLASLQVRGDGS
AMLVTTTDAFTMDDLLSGAKTAIIIHAGADNFANIPPERYVQVNGTPGPD
ETTLTTGDAGKRVACGVIGSG
Ligand information
Ligand IDCU
InChIInChI=1S/Cu/q+2
InChIKeyJPVYNHNXODAKFH-UHFFFAOYSA-N
SMILES
SoftwareSMILES
ACDLabs 10.04
OpenEye OEToolkits 1.5.0		[Cu+2]
CACTVS 3.341[Cu++]
FormulaCu
NameCOPPER (II) ION
ChEMBL
DrugBankDB14552
ZINC
PDB chain1pzs Chain A Residue 172 [Download ligand structure] [Download structure with residue number starting from 1] [View ligand structure]
Receptor-Ligand Complex Structure
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PDB1pzs Unique Features of the sodC-encoded Superoxide Dismutase from Mycobacterium tuberculosis, a Fully Functional Copper-containing Enzyme Lacking Zinc in the Active Site.
Resolution1.63 Å
Binding residue
(original residue number in PDB)		H47 H49 H126
Binding residue
(residue number reindexed from 1)		H47 H49 H126
Annotation score1
Enzymatic activity
Enzyme Commision number 1.15.1.1: superoxide dismutase.
Gene Ontology
Molecular Function
GO:0004784 superoxide dismutase activity
GO:0005507 copper ion binding
GO:0016209 antioxidant activity
GO:0016491 oxidoreductase activity
GO:0046872 metal ion binding
Biological Process
GO:0006801 superoxide metabolic process
GO:0006979 response to oxidative stress
GO:0019430 removal of superoxide radicals
GO:0033194 response to hydroperoxide
GO:0045454 cell redox homeostasis
GO:0075136 response to host
GO:0141082 symbiont-mediated detoxification of host-generated reactive oxygen species
Cellular Component
GO:0005576 extracellular region
GO:0005886 plasma membrane
GO:0009274 peptidoglycan-based cell wall

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Molecular Function
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Biological Process
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Cellular Component
External links
PDB RCSB:1pzs, PDBe:1pzs, PDBj:1pzs
PDBsum1pzs
PubMed15155722
UniProtP9WGE9|SODC_MYCTU Superoxide dismutase [Cu-Zn] (Gene Name=sodC)

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