BioLiP

InChI=1S/C25H33Cl2N7O2/c26-18-8-4-7-17(22(18)27)20-13-19(32-33-20)15-9-11-34(12-10-15)21(35)14-30-24(36)23(31-25(28)29)16-5-2-1-3-6-16/h4,7-8,13,15-16,23H,1-3,5-6,9-12,14H2,(H,30,36)(H,32,33)(H4,28,29,31)/t23-/m1/s1

InChIKey

SSSXBBASYYVGCI-HSZRJFAPSA-N

SMILES

Software	SMILES
OpenEye OEToolkits 1.5.0	c1cc(c(c(c1)Cl)Cl)c2cc([nH]n2)C3CCN(CC3)C(=O)CNC(=O)C(C4CCCCC4)NC(=N)N
CACTVS 3.341	NC(=N)N[CH](C1CCCCC1)C(=O)NCC(=O)N2CCC(CC2)c3[nH]nc(c3)c4cccc(Cl)c4Cl
OpenEye OEToolkits 1.5.0	c1cc(c(c(c1)Cl)Cl)c2cc([nH]n2)C3CCN(CC3)C(=O)CNC(=O)[C@@H](C4CCCCC4)NC(=N)N
CACTVS 3.341	NC(=N)N[C@H](C1CCCCC1)C(=O)NCC(=O)N2CCC(CC2)c3[nH]nc(c3)c4cccc(Cl)c4Cl
ACDLabs 10.04	O=C(NCC(=O)N3CCC(c1cc(nn1)c2cccc(Cl)c2Cl)CC3)C(NC(=[N@H])N)C4CCCCC4

Formula

C25 H33 Cl2 N7 O2

Name

2-CYCLOHEXYL-N-(2-{4-[5-(2,3-DICHLORO-PHENYL)-2H-PYRAZOL-3-YL]-PIPERIDIN-1-YL}-2-OXO-ETHYL)-2-GUANIDINO-ACETAMIDE;
SP2456

PDB chain

1pw6 Chain A Residue 201 [Download ligand structure] [Download structure with residue number starting from 1] [View ligand structure]

Molecular Function

GO:0005125

cytokine activity

GO:0005134

interleukin-2 receptor binding

GO:0005515

protein binding

GO:0008083

growth factor activity

GO:0019209

kinase activator activity

GO:0030246

carbohydrate binding

GO:0031851

kappa-type opioid receptor binding

GO:0043208

glycosphingolipid binding

	Biological Process
GO:0002250	adaptive immune response
GO:0002366	leukocyte activation involved in immune response
GO:0002639	positive regulation of immunoglobulin production
GO:0002903	negative regulation of B cell apoptotic process
GO:0006366	transcription by RNA polymerase II
GO:0006955	immune response
GO:0007155	cell adhesion
GO:0007186	G protein-coupled receptor signaling pathway
GO:0007204	positive regulation of cytosolic calcium ion concentration
GO:0007267	cell-cell signaling
GO:0008284	positive regulation of cell population proliferation
GO:0010467	gene expression
GO:0030101	natural killer cell activation
GO:0030217	T cell differentiation
GO:0030307	positive regulation of cell growth
GO:0030890	positive regulation of B cell proliferation
GO:0032729	positive regulation of type II interferon production
GO:0032740	positive regulation of interleukin-17 production
GO:0034105	positive regulation of tissue remodeling
GO:0038110	interleukin-2-mediated signaling pathway
GO:0042098	T cell proliferation
GO:0042102	positive regulation of T cell proliferation
GO:0042104	positive regulation of activated T cell proliferation
GO:0043066	negative regulation of apoptotic process
GO:0045471	response to ethanol
GO:0045582	positive regulation of T cell differentiation
GO:0045591	positive regulation of regulatory T cell differentiation
GO:0045944	positive regulation of transcription by RNA polymerase II
GO:0046013	regulation of T cell homeostatic proliferation
GO:0046651	lymphocyte proliferation
GO:0048304	positive regulation of isotype switching to IgG isotypes
GO:0050672	negative regulation of lymphocyte proliferation
GO:0050728	negative regulation of inflammatory response
GO:0050729	positive regulation of inflammatory response
GO:0050798	activated T cell proliferation
GO:0060999	positive regulation of dendritic spine development
GO:0097192	extrinsic apoptotic signaling pathway in absence of ligand
GO:0097696	cell surface receptor signaling pathway via STAT
GO:1900100	positive regulation of plasma cell differentiation
GO:1901327	response to tacrolimus
GO:2000320	negative regulation of T-helper 17 cell differentiation
GO:2000561	regulation of CD4-positive, alpha-beta T cell proliferation

Biological Process

GO:0002250

adaptive immune response

GO:0002366

leukocyte activation involved in immune response

GO:0002639

positive regulation of immunoglobulin production

GO:0002903

negative regulation of B cell apoptotic process

GO:0006366

transcription by RNA polymerase II

GO:0006955