Structure of PDB 1puf Chain A Binding Site BS01

Receptor Information

>1puf Chain A (length=77) Species: 10090 (Mus musculus) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]

NNPAANWLHARSTRKKRCPYTKHQTLELEKEFLFNMYLTRDRRYEVARLL
NLTERQVKIWFQNRRMKMKKINKDRAK

Ligand information

>1puf Chain D (length=20) [Search DNA sequence] [Download ligand structure] [Download structure with residue number starting from 1] [View ligand structure]

actctatgatttacgacgct

Receptor-Ligand Complex Structure

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PDB	1puf STRUCTURE OF HOXA9 AND PBX1 BOUND TO DNA: HOX HEXAPEPTIDE AND DNA RECOGNITION ANTERIOR TO POSTERIOR
Resolution	1.9 Å
Binding residue (original residue number in PDB)	R203 K207 R209 C210 P211 Y212 R247 Q248 I251 N255 K259
Binding residue (residue number reindexed from 1)	R11 K15 R17 C18 P19 Y20 R55 Q56 I59 N63 K67
Binding affinity	PDBbind-CN: Kd=0.23uM

Enzymatic activity

Enzyme Commision number

Gene Ontology

	Molecular Function
GO:0000981	DNA-binding transcription factor activity, RNA polymerase II-specific
GO:0003677	DNA binding

	Biological Process
GO:0006355	regulation of DNA-templated transcription

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Molecular Function

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Biological Process

External links

PDB	RCSB:1puf, PDBe:1puf, PDBj:1puf
PDBsum	1puf
PubMed	12923056
UniProt	P09631\|HXA9_MOUSE Homeobox protein Hox-A9 (Gene Name=Hoxa9)

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