Structure of PDB 1pnt Chain A Binding Site BS01

Receptor Information

>1pnt Chain A (length=157) Species: 9913 (Bos taurus)

AEQVTKSVLFVCLGNICRSPIAEAVFRKLVTDQNISDNWVIDSGAVSDWN
VGRSPDPRAVSCLRNHGINTAHKARQVTKEDFVTFDYILCMDESNLRDLN
RKSNQVKNCRAKIELLGSYDPQKQLIIEDPYYGNDADFETVYQQCVRCCR
AFLEKVR

Ligand information

• Ligand ID: PO4
• InChI: InChI=1S/H3O4P/c1-5(2,3)4/h(H3,1,2,3,4)/p-3
• InChIKey: NBIIXXVUZAFLBC-UHFFFAOYSA-K
• SMILES:
  CACTVS 3.341: [O-][P]([O-])([O-])=O
  ACDLabs 10.04: [O-]P([O-])([O-])=O
  OpenEye OEToolkits 1.5.0: [O-]P(=O)([O-])[O-]
• Formula: O4 P
• Name: PHOSPHATE ION
• DrugBank: DB14523
• PDB chain: 1pnt Chain A Residue 158

Receptor-Ligand Complex Structure

Structure summary

• PDB: 1pnt Crystal structure of bovine heart phosphotyrosyl phosphatase at 2.2-A resolution.
• Resolution: 2.2 Å
• Binding residue (original residue number in PDB): C12 L13 I16 C17 R18
• Binding residue (residue number reindexed from 1): C12 L13 I16 C17 R18
• Annotation score: 1

Enzymatic activity

• Catalytic site (original residue number in PDB): C12 N15 C17 R18 S19 D129
• Catalytic site (residue number reindexed from 1): C12 N15 C17 R18 S19 D129
• Enzyme Commision number: 3.1.3.2: acid phosphatase.
  3.1.3.48: protein-tyrosine-phosphatase.

Gene Ontology

Molecular Function

• GO:0003993 acid phosphatase activity
• GO:0004721 phosphoprotein phosphatase activity
• GO:0004725 protein tyrosine phosphatase activity
• GO:0004726 non-membrane spanning protein tyrosine phosphatase activity
• GO:0016791 phosphatase activity

Biological Process

• GO:0006470 protein dephosphorylation

Cellular Component

• GO:0005737 cytoplasm

External links

• PDB: RCSB:1pnt, PDBe:1pnt, PDBj:1pnt
• PDBsum: 1pnt
• PubMed: 7537084
• UniProt: P11064|PPAC_BOVIN Low molecular weight phosphotyrosine protein phosphatase (Gene Name=ACP1)