Structure of PDB 1pfg Chain A Binding Site BS01
Receptor Information
>1pfg Chain A (length=279) Species:
37998
(Parengyodontium album) [
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AAQTNAPWGLARISSTSPGTSTYYYDESAGQGSCVYVIDTGIEASHPEFE
GRAQMVKTYYYSSRDGNGHGTHCAGTVGSRTYGVVKKTQLFGVKVLDDNG
SGQYSTIIAGMDFVASDKNNRNCPKGVVASLSLGGGYSSSVNSAAARLQS
SGVMVAVAAGNNNADARNYSPASEPSVCTVGASDRYDRRSSFSNYGSVLD
IFGPGTSILSTWIGGSTRSISGTSMATPHVAGLAAYLMTLGKTTAASACR
YIADTANKGDLSNIPFGTVNLLAYNNYQA
Ligand information
>1pfg Chain B (length=8) [
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PAPFAAAA
Receptor-Ligand Complex Structure
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PDB
1pfg
Strategy to design peptide inhibitors: structure of a complex of proteinase K with a designed octapeptide inhibitor N-Ac-Pro-Ala-Pro-Phe-DAla-Ala-Ala-Ala-NH2 at 2.5 A resolution.
Resolution
2.5 Å
Binding residue
(original residue number in PDB)
N67 L133 G134 G135 N161 W212 I220 S221 T223 S224 M225
Binding residue
(residue number reindexed from 1)
N67 L133 G134 G135 N161 W212 I220 S221 T223 S224 M225
Enzymatic activity
Catalytic site (original residue number in PDB)
D39 H69 N161 S224
Catalytic site (residue number reindexed from 1)
D39 H69 N161 S224
Enzyme Commision number
3.4.21.64
: peptidase K.
Gene Ontology
Molecular Function
GO:0004252
serine-type endopeptidase activity
GO:0008236
serine-type peptidase activity
Biological Process
GO:0006508
proteolysis
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Molecular Function
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Biological Process
External links
PDB
RCSB:1pfg
,
PDBe:1pfg
,
PDBj:1pfg
PDBsum
1pfg
PubMed
8976553
UniProt
P06873
|PRTK_PARAQ Proteinase K (Gene Name=PROK)
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