Structure of PDB 1pa6 Chain A Binding Site BS01

Receptor Information

>1pa6 Chain A (length=460) Species: 200597 (Sterkiella nova)

YEYVELAKASLTSAQPQHFYAVVIDATFPYKTNQERYICSLKIVDPTLYL
KQQKGAGDASDYATLVLYAKRFEDLPIIHRAGDIIRVHRATLRLYNGQRQ
FNANVFYSSSWALFSTDKRSVTQEINNQDAVSDTTPFSFSSKHATIEKNE
ISILQNLRKWANQYFSSYSVISSDMYTALNKAQAQKGDFDVVAKILQVHE
LDEYTNELKLKDASGQVFYTLSLKLKFPHVRTGEVVRIRSATYDETSTQK
KVLILSHYSNIITFIQSSKLAKELRAKIQDDHSVEVASLKKNVSLNAVVL
TEVDKKHAALPSTSLQDLFHHADSDKELQAQDTFRTQFYVTKIEPSDVKE
WVKGYDRKTKKSSSLKGASGKGDNIFQVQFLVKDASTQLNNNTYRVLLYT
QDGLGANFFNVKADNLHKNADARKKLEDSAELLTKFNSYVDAVVERRNGF
YLIKDTKLIY

Ligand information

>1pa6 Chain D (length=12)

ggggttttgagg

Receptor-Ligand Complex Structure

Structure summary

• PDB: 1pa6 Nucleotide shuffling and ssDNA recognition in Oxytricha nova telomere end-binding protein complexes
• Resolution: 2.45 Å
• Binding residue (original residue number in PDB): Y65 K66 T67 Y72 S75 K77 F107 Y130 Q135 D223 D225 Y239 L260 K261 R274 S275 S291 H292 Y293
• Binding residue (residue number reindexed from 1): Y30 K31 T32 Y37 S40 K42 F72 Y95 Q100 D188 D190 Y204 L225 K226 R239 S240 S256 H257 Y258

Gene Ontology

Molecular Function

• GO:0003677 DNA binding
• GO:0005515 protein binding
• GO:0010521 telomerase inhibitor activity
• GO:0043047 single-stranded telomeric DNA binding
• GO:0098505 G-rich strand telomeric DNA binding

Biological Process

• GO:0000723 telomere maintenance
• GO:0016233 telomere capping
• GO:0032210 regulation of telomere maintenance via telomerase

Cellular Component

• GO:0000781 chromosome, telomeric region
• GO:0000782 telomere cap complex
• GO:0000783 nuclear telomere cap complex
• GO:0005634 nucleus
• GO:0005694 chromosome
• GO:0032991 protein-containing complex

External links

• PDB: RCSB:1pa6, PDBe:1pa6, PDBj:1pa6
• PDBsum: 1pa6
• PubMed: 12912928
• UniProt: P29549|TEBA_STENO Telomere-binding protein subunit alpha (Gene Name=MAC-56A)