Structure of PDB 1p7t Chain A Binding Site BS01

Receptor Information
>1p7t Chain A (length=706) Species: 316407 (Escherichia coli str. K-12 substr. W3110) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
TITQSRLRIDANFKRFVDEEVLPGTGLDAAAFWRNFDEIVHDLAPENRQL
LAERDRIQAALDEWHRSNPGPVKDKAAYKSFLRELGYLVPQPERVTVETT
GIDSEITSQAGPQLVVPAMNARYALNAANARWGSLYDALYGSDIIPQDPQ
RGEQVIAWVRRFLDESLPLENGSYQDVVAFKVVDKQLRIQLKNGKETTLR
TPAQFVGYRGDAAAPTCILLKNNGLHIELQIDANGRIGKDDPAHINDVIV
EAAISTILDCEDSVAAVDAEDKILLYRNLLGLMQGTLQEKMQIVRKLNDD
RHYTAADGSEISLHGRSLLFIRNVGHLMTIPVIWDSEGNEIPEGILDGVM
TGAIALYDLKVQKNSRTGSVYIVKPKMHGPQEVAFANKLFTRIETMLGMA
PNTLKMGIMDEERRTSLNLRSCIAQARNRVAFINTGFLDRTGDEMHSVME
AGPMLRKNQMKSTPWIKAYERNNVLSGLFCGLRGKAQIGKGMWAMPDLMA
DMYSQKGDQLRAGANTAWVPSPTAATLHALHYHQTNVQSVQANIAQTEFN
AEFEPLLDDLLTIPVAENANWSAQEIQQELDNNVQGILGYVVRWVEQGIG
CSKVPDIHNVALMEDRATLRISSQHIANWLRHGILTKEQVQASLENMAKV
VDQQNAGDPAYRPMAGNFANSCAFKAASDLIFLGVKQPNGYTEPLLHAWR
LREKES
Ligand information
Ligand IDMG
InChIInChI=1S/Mg/q+2
InChIKeyJLVVSXFLKOJNIY-UHFFFAOYSA-N
SMILES
SoftwareSMILES
ACDLabs 10.04
OpenEye OEToolkits 1.5.0		[Mg+2]
CACTVS 3.341[Mg++]
FormulaMg
NameMAGNESIUM ION
ChEMBL
DrugBankDB01378
ZINC
PDB chain1p7t Chain A Residue 1000 [Download ligand structure] [Download structure with residue number starting from 1] [View ligand structure]
Receptor-Ligand Complex Structure
Global viewLocal viewStructure summary

[Spin on] [Spin off] [Reset]
[High quality] [Low quality]
[White background] [Black background]
[Spin on] [Spin off] [Reset]
[High quality] [Low quality]
[White background] [Black background]
PDB1p7t Structure of the Escherichia Coli Malate Synthase G:pyruvate:acetyl-coenzyme A Abortive Ternary Complex at 1.95 Angstrom Resolution
Resolution1.95 Å
Binding residue
(original residue number in PDB)		E427 D455
Binding residue
(residue number reindexed from 1)		E411 D439
Annotation score1
Enzymatic activity
Catalytic site (original residue number in PDB) D270 E272 R338 E427 D455 D631
Catalytic site (residue number reindexed from 1) D259 E261 R322 E411 D439 D615
Enzyme Commision number 2.3.3.9: malate synthase.
Gene Ontology
Molecular Function
GO:0000287 magnesium ion binding
GO:0003824 catalytic activity
GO:0004474 malate synthase activity
GO:0016740 transferase activity
GO:0046872 metal ion binding
Biological Process
GO:0006097 glyoxylate cycle
GO:0006099 tricarboxylic acid cycle
GO:0009436 glyoxylate catabolic process
Cellular Component
GO:0005737 cytoplasm
GO:0005829 cytosol

View graph for
Molecular Function
View graph for
Biological Process
View graph for
Cellular Component
External links
PDB RCSB:1p7t, PDBe:1p7t, PDBj:1p7t
PDBsum1p7t
PubMed12930982
UniProtP37330|MASZ_ECOLI Malate synthase G (Gene Name=glcB)

[Back to BioLiP]