Structure of PDB 1p4v Chain A Binding Site BS01

Receptor Information
>1p4v Chain A (length=295) Species: 238 (Elizabethkingia meningoseptica) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
TTNKPIVLSTWNFGLHANVEAWKVLSKGGKALDAVEKGVRLVEDDPTERS
VGYGGRPDRDGRVTLDACIMDENYNIGSVACMEHIKNPISVARAVMEKTP
HVMLVGDGALEFALSQGFKKENLLTAESEKEWKEWLKTSQYKPIVNIENH
NTIGMIALDAQGNLSGACTTSGMAYKMHGRVGDSPIIGAGLFVDNEIGAA
TATGHGEEVIRTVGTHLVVELMNQGRTPQQACKEAVERIVKIVNRRGKNL
KDIQVGFIALNKKGEYGAYCIQDGFNFAVHDQKGNRLETPGFALK
Ligand information
Ligand IDGLY
InChIInChI=1S/C2H5NO2/c3-1-2(4)5/h1,3H2,(H,4,5)
InChIKeyDHMQDGOQFOQNFH-UHFFFAOYSA-N
SMILES
SoftwareSMILES
OpenEye OEToolkits 1.5.0C(C(=O)O)N
CACTVS 3.341NCC(O)=O
ACDLabs 10.04O=C(O)CN
FormulaC2 H5 N O2
NameGLYCINE
ChEMBLCHEMBL773
DrugBankDB00145
ZINCZINC000004658552
PDB chain1p4v Chain A Residue 296 [Download ligand structure] [Download structure with residue number starting from 1] [View ligand structure]
Receptor-Ligand Complex Structure
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PDB1p4v A dual role for an aspartic acid in glycosylasparaginase autoproteolysis.
Resolution1.9 Å
Binding residue
(original residue number in PDB)		R180 D183 G206
Binding residue
(residue number reindexed from 1)		R180 D183 G206
Annotation score1
Enzymatic activity
Catalytic site (original residue number in PDB) T152
Catalytic site (residue number reindexed from 1) T152
Enzyme Commision number 3.5.1.26: N(4)-(beta-N-acetylglucosaminyl)-L-asparaginase.
Gene Ontology
Molecular Function
GO:0003948 N4-(beta-N-acetylglucosaminyl)-L-asparaginase activity
GO:0004067 asparaginase activity
GO:0008233 peptidase activity
GO:0008798 beta-aspartyl-peptidase activity
GO:0016787 hydrolase activity
Biological Process
GO:0006508 proteolysis
GO:0006517 protein deglycosylation
Cellular Component
GO:0005737 cytoplasm
GO:0042597 periplasmic space

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Molecular Function
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Biological Process
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Cellular Component
External links
PDB RCSB:1p4v, PDBe:1p4v, PDBj:1p4v
PDBsum1p4v
PubMed12906830
UniProtQ47898|ASPG_ELIMR N(4)-(Beta-N-acetylglucosaminyl)-L-asparaginase

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