Structure of PDB 1p22 Chain A Binding Site BS01
Receptor Information
>1p22 Chain A (length=402) Species:
9606
(Homo sapiens) [
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SPAIMLQRDFITALPARGLDHIAENILSYLDAKSLCAAELVCKEWYRVTS
DGMLWKKLIERMVRTDSLWRGLAERRGWGQYLFPPNSFYRALYPKIIQDI
ETIESNWRCGRHSLQRIHCRSETSKGVYCLQYDDQKIVSGLRDNTIKIWD
KNTLECKRILTGHTGSVLCLQYDERVIITGSSDSTVRVWDVNTGEMLNTL
IHHCEAVLHLRFNNGMMVTCSKDRSIAVWDMASPTDITLRRVLVGHRAAV
NVVDFDDKYIVSASGDRTIKVWNTSTCEFVRTLNGHKRGIACLQYRDRLV
VSGSSDNTIRLWDIECGACLRVLEGHEELVRCIRFDNKRIVSGAYDGKIK
VWDLVAALDPRAPAGTLCLRTLVEHSGRVFRLQFDEFQIVSSSHDDTILI
WD
Ligand information
>1p22 Chain C (length=11) Species:
9606
(Homo sapiens) [
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YLDSGIHSGAT
Receptor-Ligand Complex Structure
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PDB
1p22
Structure of a beta-TrCP1-Skp1-beta-Catenin complex: destruction motif binding and lysine specificity of the SCFbeta-TrCP1 ubiquitin ligase
Resolution
2.95 Å
Binding residue
(original residue number in PDB)
Y271 R285 S309 L311 S325 L351 K365 R367 N394 G408 R431 G432 S448 R474 Y488 R521 F523
Binding residue
(residue number reindexed from 1)
Y128 R142 S166 L168 S182 L208 K222 R224 N251 G265 R288 G289 S305 R331 Y345 R378 F380
Enzymatic activity
Enzyme Commision number
?
External links
PDB
RCSB:1p22
,
PDBe:1p22
,
PDBj:1p22
PDBsum
1p22
PubMed
12820959
UniProt
Q9Y297
|FBW1A_HUMAN F-box/WD repeat-containing protein 1A (Gene Name=BTRC)
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