Structure of PDB 1otc Chain A Binding Site BS01

Receptor Information

>1otc Chain A (length=459) Species: 200597 (Sterkiella nova)

EYVELAKASLTSAQPQHFYAVVIDATFPYKTNQERYICSLKIVDPTLYLK
QQKGAGDASDYATLVLYAKRFEDLPIIHRAGDIIRVHRATLRLYNGQRQF
NANVFYSSSWALFSTDKRSVTQEINNQDAVSDTTPFSFSSKHATIEKNEI
SILQNLRKWANQYFSSYSVISSDMYTALNKAQAQKGDFDVVAKILQVHEL
DEYTNELKLKDASGQVFYTLSLKLKFPHVRTGEVVRIRSATYDETSTQKK
VLILSHYSNIITFIQSSKLAKELRAKIQDDHSVEVASLKKNVSLNAVVLT
EVDKKHAALPSTSLQDLFHHADSDKELQAQDTFRTQFYVTKIEPSDVKEW
VKGYDRKTKKSSSLKGASGKGDNIFQVQFLVKDASTQLNNNTYRVLLYTQ
DGLGANFFNVKADNLHKNADARKKLEDSAELLTKFNSYVDAVVERRNGFY
LIKDTKLIY

Ligand information

>1otc Chain D (length=12)

ggggttttgggg

Receptor-Ligand Complex Structure

Structure summary

• PDB: 1otc Crystal structure of the Oxytricha nova telomere end binding protein complexed with single strand DNA.
• Resolution: 2.8 Å
• Binding residue (original residue number in PDB): F63 P64 Y65 K66 Q69 Y72 I73 S75 K77 V101 F107 I112 Y130 Q135 D223 D225 Y239 T240 L260 K261 R274 H292 Y293
• Binding residue (residue number reindexed from 1): F27 P28 Y29 K30 Q33 Y36 I37 S39 K41 V65 F71 I76 Y94 Q99 D187 D189 Y203 T204 L224 K225 R238 H256 Y257

Gene Ontology

Molecular Function

• GO:0003677 DNA binding
• GO:0005515 protein binding
• GO:0010521 telomerase inhibitor activity
• GO:0043047 single-stranded telomeric DNA binding
• GO:0098505 G-rich strand telomeric DNA binding

Biological Process

• GO:0000723 telomere maintenance
• GO:0016233 telomere capping
• GO:0032210 regulation of telomere maintenance via telomerase

Cellular Component

• GO:0000781 chromosome, telomeric region
• GO:0000782 telomere cap complex
• GO:0000783 nuclear telomere cap complex
• GO:0005634 nucleus
• GO:0005694 chromosome
• GO:0032991 protein-containing complex

External links

• PDB: RCSB:1otc, PDBe:1otc, PDBj:1otc
• PDBsum: 1otc
• PubMed: 9875850
• UniProt: P29549|TEBA_STENO Telomere-binding protein subunit alpha (Gene Name=MAC-56A)