Structure of PDB 1orf Chain A Binding Site BS01
Receptor Information
>1orf Chain A (length=232) Species:
9606
(Homo sapiens) [
Search protein sequence
] [
Download receptor structure
] [
Download structure with residue number starting from 1
] [
View receptor structure
]
IIGGNEVTPHSRPYMVLLSLDRKTICAGALIAKDWVLTAAHCNLNKRSQV
ILGAHSITREEPTKQIMLVKKEFPYPCYDPATREGDLKLLQLTEKAKINK
YVTILHLPKKGDDVKPGTMCQVAGWGRTHNSASWSDTLREVEITIIDRKV
CNDRNHYNFNPVIGMNMVCAGSLRGGRDSCNGDSGSPLLCEGVFRGVTSF
GLENKCGDPRGPGVYILLSKKHLNWIIMTIKG
Ligand information
Ligand ID
0G6
InChI
InChI=1S/C21H33ClN6O3/c22-13-18(29)16(8-4-10-26-21(24)25)27-19(30)17-9-5-11-28(17)20(31)15(23)12-14-6-2-1-3-7-14/h1-3,6-7,15-18,29H,4-5,8-13,23H2,(H,27,30)(H4,24,25,26)/p+1/t15-,16+,17+,18-/m1/s1
InChIKey
DVFLYEYCMMLBTQ-VSZNYVQBSA-O
SMILES
Software
SMILES
ACDLabs 12.01
O=C(NC(CCCNC(=[NH2+])\N)C(O)CCl)C2N(C(=O)C(N)Cc1ccccc1)CCC2
CACTVS 3.370
N[CH](Cc1ccccc1)C(=O)N2CCC[CH]2C(=O)N[CH](CCCNC(N)=[NH2+])[CH](O)CCl
CACTVS 3.370
N[C@H](Cc1ccccc1)C(=O)N2CCC[C@H]2C(=O)N[C@@H](CCCNC(N)=[NH2+])[C@H](O)CCl
OpenEye OEToolkits 1.7.6
c1ccc(cc1)CC(C(=O)N2CCCC2C(=O)NC(CCCNC(=[NH2+])N)C(CCl)O)N
OpenEye OEToolkits 1.7.6
c1ccc(cc1)C[C@H](C(=O)N2CCC[C@H]2C(=O)N[C@@H](CCCNC(=[NH2+])N)[C@@H](CCl)O)N
Formula
C21 H34 Cl N6 O3
Name
D-phenylalanyl-N-[(2S,3S)-6-{[amino(iminio)methyl]amino}-1-chloro-2-hydroxyhexan-3-yl]-L-prolinamide;
PPACK
ChEMBL
DrugBank
DB06841
ZINC
PDB chain
1orf Chain A Residue 1 [
Download ligand structure
] [
Download structure with residue number starting from 1
] [
View ligand structure
]
Receptor-Ligand Complex Structure
Global view
Local view
Structure summary
[
Spin on
] [
Spin off
] [
Reset
]
[
High quality
] [
Low quality
]
[
White background
] [
Black background
]
[
Spin on
] [
Spin off
] [
Reset
]
[
High quality
] [
Low quality
]
[
White background
] [
Black background
]
PDB
1orf
The oligomeric structure of human granzyme A is a determinant of its extended substrate specificity.
Resolution
2.4 Å
Binding residue
(original residue number in PDB)
H57 R99 D189 S190 C191 G193 S195 S214 F215 G216
Binding residue
(residue number reindexed from 1)
H41 R83 D178 S179 C180 G182 S184 S199 F200 G201
Annotation score
1
Enzymatic activity
Catalytic site (original residue number in PDB)
H57 D102 N192 G193 D194 S195 G196
Catalytic site (residue number reindexed from 1)
H41 D86 N181 G182 D183 S184 G185
Enzyme Commision number
3.4.21.78
: granzyme A.
Gene Ontology
Molecular Function
GO:0004252
serine-type endopeptidase activity
GO:0005515
protein binding
GO:0008236
serine-type peptidase activity
GO:0042803
protein homodimerization activity
Biological Process
GO:0006508
proteolysis
GO:0006915
apoptotic process
GO:0006955
immune response
GO:0009617
response to bacterium
GO:0031640
killing of cells of another organism
GO:0032078
negative regulation of endodeoxyribonuclease activity
GO:0043065
positive regulation of apoptotic process
GO:0043392
negative regulation of DNA binding
GO:0051354
negative regulation of oxidoreductase activity
GO:0051603
proteolysis involved in protein catabolic process
GO:0051604
protein maturation
GO:0070269
pyroptotic inflammatory response
GO:0140507
granzyme-mediated programmed cell death signaling pathway
GO:1902483
cytotoxic T cell pyroptotic cell death
Cellular Component
GO:0001772
immunological synapse
GO:0005576
extracellular region
GO:0005615
extracellular space
GO:0005634
nucleus
GO:0005737
cytoplasm
View graph for
Molecular Function
View graph for
Biological Process
View graph for
Cellular Component
External links
PDB
RCSB:1orf
,
PDBe:1orf
,
PDBj:1orf
PDBsum
1orf
PubMed
12819769
UniProt
P12544
|GRAA_HUMAN Granzyme A (Gene Name=GZMA)
[
Back to BioLiP
]