Structure of PDB 1olt Chain A Binding Site BS01
Receptor Information
>1olt Chain A (length=434) Species:
83333
(Escherichia coli K-12) [
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QQIDWDLALIKYYTSYPTALEFSEDFGEQAFLQAVARYPERPLSLYVHIP
FCHKLCYFCGCNKIVTRQQHKADQYLDALEQEIVHRAPLFAGRHVSQLHW
GGGTPTYLNKAQISRLMKLLRENFQFNADAEISIEVDPREIELDVLDHLR
AEGFNRLSMGVQDFNKEVQRLVNREQDEEFIFALLNHAREIGFTSTNIDL
IYGLPKQTPESFAFTLKRVAELNPDRLSVFNYAHLPTIFAAQRKIKDADL
PSPQQKLDILQETIAFLTQSGYQFIGMDHFARPDDELAVAQREGVLHRNF
QGYTTQGDTDLLGMGVSAISMIGDCYAQNQKELKQYYQQVDEQGNALWRG
IALTRDDCIRRDVIKSLICNFRLDYSPIEQQWDLLFADYFAEDLKLLAPL
AKDGLVDVDEKGIQVTAKGRLLIRNICMCFDTYL
Ligand information
Ligand ID
SF4
InChI
InChI=1S/4Fe.4S
InChIKey
LJBDFODJNLIPKO-UHFFFAOYSA-N
SMILES
Software
SMILES
OpenEye OEToolkits 2.0.7
[S]12[Fe]3[S]4[Fe]1[S]5[Fe]2[S]3[Fe]45
CACTVS 3.385
S1[Fe]S[Fe]1.S2[Fe]S[Fe]2
Formula
Fe4 S4
Name
IRON/SULFUR CLUSTER
ChEMBL
DrugBank
ZINC
PDB chain
1olt Chain A Residue 500 [
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Receptor-Ligand Complex Structure
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PDB
1olt
Crystal Structure of Coproporphyrinogen III Oxidase Reveals Cofactor Geometry of Radical Sam Enzymes
Resolution
2.07 Å
Binding residue
(original residue number in PDB)
C62 C66 F68 C69 K73 G113 T114 R184
Binding residue
(residue number reindexed from 1)
C52 C56 F58 C59 K63 G103 T104 R174
Annotation score
1
Enzymatic activity
Enzyme Commision number
1.3.98.3
: coproporphyrinogen dehydrogenase.
Gene Ontology
Molecular Function
GO:0003824
catalytic activity
GO:0004109
coproporphyrinogen oxidase activity
GO:0016491
oxidoreductase activity
GO:0046872
metal ion binding
GO:0051536
iron-sulfur cluster binding
GO:0051539
4 iron, 4 sulfur cluster binding
GO:0051989
coproporphyrinogen dehydrogenase activity
Biological Process
GO:0006779
porphyrin-containing compound biosynthetic process
GO:0006782
protoporphyrinogen IX biosynthetic process
GO:0019353
protoporphyrinogen IX biosynthetic process from glutamate
Cellular Component
GO:0005737
cytoplasm
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Molecular Function
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Biological Process
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Cellular Component
External links
PDB
RCSB:1olt
,
PDBe:1olt
,
PDBj:1olt
PDBsum
1olt
PubMed
14633981
UniProt
P32131
|HEMN_ECOLI Oxygen-independent coproporphyrinogen III oxidase (Gene Name=hemN)
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