Structure of PDB 1oht Chain A Binding Site BS01

Receptor Information
>1oht Chain A (length=173) Species: 7227 (Drosophila melanogaster) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
TARLLSRSDWGARLPKSVEHFQGPAPYVIIHHSYMPAVCYSTPDCMKSMR
DMQDFHQLERGWNDIGYSFGIGGDGMIYTGRGFNVIGAHAPKYNDKSVGI
VLIGDWRTELPPKQMLDAAKNLIAFGVFKGYIDPAYKLLGHRQVRDTECP
GGRLFAEISSWPHFTHINDTEGV
Ligand information
Ligand IDZN
InChIInChI=1S/Zn/q+2
InChIKeyPTFCDOFLOPIGGS-UHFFFAOYSA-N
SMILES
SoftwareSMILES
CACTVS 3.341[Zn++]
ACDLabs 10.04
OpenEye OEToolkits 1.5.0		[Zn+2]
FormulaZn
NameZINC ION
ChEMBLCHEMBL1236970
DrugBankDB14532
ZINC
PDB chain1oht Chain A Residue 1185 [Download ligand structure] [Download structure with residue number starting from 1] [View ligand structure]
Receptor-Ligand Complex Structure
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PDB1oht Crystal Structure of Peptidoglycan Recognition Protein Lb from Drosophila Melanogaster
Resolution2.0 Å
Binding residue
(original residue number in PDB)		H42 H152 C160 V184
Binding residue
(residue number reindexed from 1)		H31 H141 C149 V173
Annotation score4
Enzymatic activity
Catalytic site (original residue number in PDB) Y78
Catalytic site (residue number reindexed from 1) Y67
Enzyme Commision number 3.5.1.28: N-acetylmuramoyl-L-alanine amidase.
Gene Ontology
Molecular Function
GO:0005515 protein binding
GO:0008270 zinc ion binding
GO:0008745 N-acetylmuramoyl-L-alanine amidase activity
GO:0016787 hydrolase activity
GO:0042834 peptidoglycan binding
GO:0046872 metal ion binding
Biological Process
GO:0002814 negative regulation of biosynthetic process of antibacterial peptides active against Gram-negative bacteria
GO:0009253 peptidoglycan catabolic process
GO:0045087 innate immune response
GO:0050830 defense response to Gram-positive bacterium
GO:0061060 negative regulation of peptidoglycan recognition protein signaling pathway
Cellular Component
GO:0005576 extracellular region

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Molecular Function
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Biological Process
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Cellular Component
External links
PDB RCSB:1oht, PDBe:1oht, PDBj:1oht
PDBsum1oht
PubMed12845326
UniProtQ8INK6|PGPLB_DROME Peptidoglycan-recognition protein LB (Gene Name=PGRP-LB)

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