Structure of PDB 1odl Chain A Binding Site BS01

Receptor Information

>1odl Chain A (length=234) Species: 300852 (Thermus thermophilus HB8)

SPIHVRAHPGDVAERVLLPGDPGRAEWIAKTFLQNPRRYNDHRGLWGYTG
LYKGVPVSVQTTGMGTPSAAIVVEELVRLGARVLVRVGTAGAASSDLAPG
ELIVAQGAVPLDGTTRQYLEGRPYAPVPDPEVFRALWRRAEALGYPHRVG
LVASEDAFYATTPEEARAWARYGVLAFEMEASALFLLGRMRGVRTGAILA
VSNRIGDPELAPPEVLQEGVRRMVEVALEAVLEV

Ligand information

• Ligand ID: SO4
• InChI: InChI=1S/H2O4S/c1-5(2,3)4/h(H2,1,2,3,4)/p-2
• InChIKey: QAOWNCQODCNURD-UHFFFAOYSA-L
• SMILES:
  OpenEye OEToolkits 1.5.0: [O-]S(=O)(=O)[O-]
  CACTVS 3.341: [O-][S]([O-])(=O)=O
  ACDLabs 10.04: [O-]S([O-])(=O)=O
• Formula: O4 S
• Name: SULFATE ION
• DrugBank: DB14546
• PDB chain: 1odl Chain A Residue 1236

Receptor-Ligand Complex Structure

Structure summary

• PDB: 1odl Crystal Structure of Purine Nucleoside Phosphorylase from Thermus Thermophilus
• Resolution: 2.1 Å
• Binding residue (original residue number in PDB): G21 R25 R87 G89 T90
• Binding residue (residue number reindexed from 1): G20 R24 R86 G88 T89
• Annotation score: 1

Enzymatic activity

• Catalytic site (original residue number in PDB): H5 G21 R25 R44 E76 R87 T90 S203 N204 I206 L217
• Catalytic site (residue number reindexed from 1): H4 G20 R24 R43 E75 R86 T89 S202 N203 I205 L216
• Enzyme Commision number: 2.4.2.3: uridine phosphorylase.

Gene Ontology

Molecular Function

• GO:0003824 catalytic activity
• GO:0016757 glycosyltransferase activity
• GO:0016763 pentosyltransferase activity

Biological Process

• GO:0009116 nucleoside metabolic process
• GO:0009164 nucleoside catabolic process

Cellular Component

• GO:0005829 cytosol

External links

• PDB: RCSB:1odl, PDBe:1odl, PDBj:1odl
• PDBsum: 1odl
• PubMed: 15046984
• UniProt: Q5SID9