Structure of PDB 1o98 Chain A Binding Site BS01

Receptor Information
>1o98 Chain A (length=509) Species: 1422 (Geobacillus stearothermophilus) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
SKKPVALIILDGFALRDETYGNAVAQANKPNFDRYWNEYPHTTLKACGEA
VGLPEGQMGNSEVGHLNIGAGRIVYQSLTRINIAIREGEFDRNETFLAAM
NHVKQHGTSLHLFGLLSDGGVHSHIHHLYALLRLAAKEGVKRVYIHGFLD
GRDVGPQTAPQYIKELQEKIKEYGVGEIATLSGRYYSMDRDKRWDRVEKA
YRAMVYGEGPTYRDPLECIEDSYKHGIYDEFVLPSVIVREDGRPVATIQD
NDAIIFYNFRPDRAIQISNTFTNEDFREFDRGPKHPKHLFFVCLTHFSET
VAGYVAFKPTNLDNTIGEVLSQHGLRQLRIAETEKYPHVTFFMSGGREEE
FPGEDRILINSPKVPTYDLKPEMSAYEVTDALLKEIEADKYDAIILNYAN
PDMVGHSGKLEPTIKAVEAVDECLGKVVDAILAKGGIAIITADHGNADEV
LTPDGKPQTAHTTNPVPVIVTKKGIKLRDGGILGDLAPTMLDLLGLPQPK
EMTGKSLIV
Ligand information
Ligand IDMN
InChIInChI=1S/Mn/q+2
InChIKeyWAEMQWOKJMHJLA-UHFFFAOYSA-N
SMILES
SoftwareSMILES
ACDLabs 10.04
OpenEye OEToolkits 1.5.0		[Mn+2]
CACTVS 3.341[Mn++]
FormulaMn
NameMANGANESE (II) ION
ChEMBL
DrugBankDB06757
ZINC
PDB chain1o98 Chain A Residue 601 [Download ligand structure] [Download structure with residue number starting from 1] [View ligand structure]
Receptor-Ligand Complex Structure
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PDB1o98 Insights Into the Catalytic Mechanism of Cofactor-Independent Phosphoglycerate Mutase from X-Ray Crystallography, Simulated Dynamics and Molecular Modeling
Resolution1.4 Å
Binding residue
(original residue number in PDB)		D403 H407 H462
Binding residue
(residue number reindexed from 1)		D402 H406 H461
Annotation score1
Enzymatic activity
Catalytic site (original residue number in PDB) D12 S62 D154 R261 K336 D403 H407 D444 H445 H462
Catalytic site (residue number reindexed from 1) D11 S61 D153 R260 K335 D402 H406 D443 H444 H461
Enzyme Commision number 5.4.2.12: phosphoglycerate mutase (2,3-diphosphoglycerate-independent).
Gene Ontology
Molecular Function
GO:0003824 catalytic activity
GO:0004619 phosphoglycerate mutase activity
GO:0016853 isomerase activity
GO:0030145 manganese ion binding
GO:0046537 2,3-bisphosphoglycerate-independent phosphoglycerate mutase activity
GO:0046872 metal ion binding
Biological Process
GO:0006007 glucose catabolic process
GO:0006096 glycolytic process
GO:0030435 sporulation resulting in formation of a cellular spore
GO:0043937 regulation of sporulation
Cellular Component
GO:0005737 cytoplasm
GO:0005829 cytosol

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Molecular Function
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Biological Process
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Cellular Component
External links
PDB RCSB:1o98, PDBe:1o98, PDBj:1o98
PDBsum1o98
PubMed12729763
UniProtQ9X519|GPMI_GEOSE 2,3-bisphosphoglycerate-independent phosphoglycerate mutase (Gene Name=gpmI)

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