Structure of PDB 1o5x Chain A Binding Site BS01

Receptor Information

>1o5x Chain A (length=246) Species: 5833 (Plasmodium falciparum)

RKYFVAANWKCNGTLESIKSLTNSFNNLDFDPSKLDVVVFPVSVHYDHTR
KLLQSKFSTGIQNVSKFGNGSYTGEVSAEIAKDLNIEYVIIGHFERRKYF
HETDEDVREKLQASLKNNLKAVVCFGESLEQREQNKTIEVITKQVKAFVD
LIDNFDNVILVYEPLWAIGTGKTATPEQAQLVHKEIRKIVKDTCGEKQAN
QIRILYGGSVNTENCSSLIQQEDIDGFLVGNASLKESFVDIIKSAM

Ligand information

• Ligand ID: PO3
• InChI: InChI=1S/O3P/c1-4(2)3/q-3
• InChIKey: AQSJGOWTSHOLKH-UHFFFAOYSA-N
• SMILES:
  CACTVS 3.341: [O-][P-]([O-])=O
  ACDLabs 10.04: [O-][PH2-]([O-])=O
  OpenEye OEToolkits 1.5.0: [O-][P-](=O)[O-]
• Formula: O3 P
• Name: PHOSPHITE ION
• PDB chain: 1o5x Chain A Residue 6000

Receptor-Ligand Complex Structure

Structure summary

• PDB: 1o5x Structure of Plasmodium falciparum Triose-phosphate Isomerase-2-Phosphoglycerate Complex at 1.1-A Resolution
• Resolution: 1.1 Å
• Binding residue (original residue number in PDB): G232 N233
• Binding residue (residue number reindexed from 1): G230 N231
• Annotation score: 1

Enzymatic activity

• Catalytic site (original residue number in PDB): N10 K12 H95 E97 E165 G171 S211
• Catalytic site (residue number reindexed from 1): N8 K10 H93 E95 E163 G169 S209
• Enzyme Commision number: 5.3.1.1: triose-phosphate isomerase.

Gene Ontology

Molecular Function

• GO:0004807 triose-phosphate isomerase activity
• GO:0016853 isomerase activity
• GO:0042802 identical protein binding

Biological Process

• GO:0006094 gluconeogenesis
• GO:0006096 glycolytic process
• GO:0019563 glycerol catabolic process
• GO:0046166 glyceraldehyde-3-phosphate biosynthetic process

Cellular Component

• GO:0005829 cytosol

External links

• PDB: RCSB:1o5x, PDBe:1o5x, PDBj:1o5x
• PDBsum: 1o5x
• PubMed: 14563846
• UniProt: Q07412|TPIS_PLAFA Triosephosphate isomerase (Gene Name=TPI)