Structure of PDB 1o2f Chain A Binding Site BS01

Receptor Information
>1o2f Chain A (length=150) Species: 562 (Escherichia coli) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
TIEIIAPLSGEIVNIEDVPDVVFAEKIVGDGIAIKPTGNKMVAPVDGTIG
KIFETNHAFSIESDSGVELFVHFGIDTVELKGEGFKRIAEEGQRVKVGDT
VIEFDLPLLEEKAKSTLTPVVISNMDEIKELIKLSGSVTVGETPVIRIKK
Ligand information
Ligand IDPO3
InChIInChI=1S/O3P/c1-4(2)3/q-3
InChIKeyAQSJGOWTSHOLKH-UHFFFAOYSA-N
SMILES
SoftwareSMILES
CACTVS 3.341[O-][P-]([O-])=O
ACDLabs 10.04[O-][PH2-]([O-])=O
OpenEye OEToolkits 1.5.0[O-][P-](=O)[O-]
FormulaO3 P
NamePHOSPHITE ION
ChEMBL
DrugBank
ZINC
PDB chain1o2f Chain B Residue 200 [Download ligand structure] [Download structure with residue number starting from 1] [View ligand structure]
Receptor-Ligand Complex Structure
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PDB1o2f Solution Structure of the Phosphoryl Transfer Complex between the Signal-transducing Protein IIAGlucose and the Cytoplasmic Domain of the Glucose Transporter IICBGlucose of the Escherichia coli Glucose Phosphotransferase System.
ResolutionN/A
Binding residue
(original residue number in PDB)		H90 D94
Binding residue
(residue number reindexed from 1)		H72 D76
Annotation score1
Enzymatic activity
Catalytic site (original residue number in PDB) T73 H75 H90
Catalytic site (residue number reindexed from 1) T55 H57 H72
Enzyme Commision number 2.7.1.69: Transferred entry: 2.7.1.191, 2.7.1.192, 2.7.1.193, 2.7.1.194, 2.7.1.195, 2.7.1.196, 2.7.1.197, 2.7.1.198, 2.7.1.199, 2.7.1.200, 2.7.1.201, 2.7.1.202, 2.7.1.203, 2.7.1.204, 2.7.1.205, 2.7.1.206, 2.7.1.207 and 2.7.1.208.
Gene Ontology
Molecular Function
GO:0005515 protein binding
GO:0016301 kinase activity
GO:0046872 metal ion binding
Biological Process
GO:0009401 phosphoenolpyruvate-dependent sugar phosphotransferase system
GO:0016310 phosphorylation
GO:0034763 negative regulation of transmembrane transport
GO:0043610 regulation of carbohydrate utilization
GO:0045912 negative regulation of carbohydrate metabolic process
GO:1902344 negative regulation of maltose transport
Cellular Component
GO:0005737 cytoplasm
GO:0005829 cytosol
GO:0009898 cytoplasmic side of plasma membrane
GO:0016020 membrane
GO:1902495 transmembrane transporter complex
GO:1990154 enzyme IIA-maltose transporter complex

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Molecular Function
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Biological Process
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Cellular Component
External links
PDB RCSB:1o2f, PDBe:1o2f, PDBj:1o2f
PDBsum1o2f
PubMed12716891
UniProtP69783|PTGA_ECOLI PTS system glucose-specific EIIA component (Gene Name=crr)

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