Structure of PDB 1nzi Chain A Binding Site BS01

Receptor Information
>1nzi Chain A (length=155) Species: 9606 (Homo sapiens) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
EPTMYGEILSPNYPQAYPSEVEKSWDIEVPEGYGIHLYFTHLDIELSENC
AYDSVQIISEEGRLCGQRSSNNPHSPIVEEFQVPYNKLQVIFKSDFSNEE
RFTGFAAYYVATDINECTDVDVPCSHFCNNFIGGYFCSCPPEYFLHDDMK
NCGVN
Ligand information
Ligand IDCA
InChIInChI=1S/Ca/q+2
InChIKeyBHPQYMZQTOCNFJ-UHFFFAOYSA-N
SMILES
SoftwareSMILES
CACTVS 3.341[Ca++]
ACDLabs 10.04
OpenEye OEToolkits 1.5.0		[Ca+2]
FormulaCa
NameCALCIUM ION
ChEMBL
DrugBankDB14577
ZINC
PDB chain1nzi Chain A Residue 1001 [Download ligand structure] [Download structure with residue number starting from 1] [View ligand structure]
Receptor-Ligand Complex Structure
Global viewLocal viewStructure summary

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PDB1nzi X-ray structure of the Ca2+-binding interaction domain of C1s. Insights into the assembly of the C1 complex of complement
Resolution1.5 Å
Binding residue
(original residue number in PDB)		D116 I117 E119 N134 F135 G138
Binding residue
(residue number reindexed from 1)		D113 I114 E116 N130 F131 G134
Annotation score4
Enzymatic activity
Enzyme Commision number 3.4.21.42: complement subcomponent C1s.
Gene Ontology
Molecular Function
GO:0005509 calcium ion binding

View graph for
Molecular Function
External links
PDB RCSB:1nzi, PDBe:1nzi, PDBj:1nzi
PDBsum1nzi
PubMed12788922
UniProtP09871|C1S_HUMAN Complement C1s subcomponent (Gene Name=C1S)

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