Structure of PDB 1nwg Chain A Binding Site BS01

Receptor Information

>1nwg Chain A (length=123) Species: 10090 (Mus musculus)

TELTKCKVSHAIKDIDGYQGISLLEWACVLFHTSGYDTQAVVNDNGSTEY
GLFQISDRFWCKSSEFPESENICGISCDKLLDDELDDDIACAKKILAIKG
IDYWKAYKPMCSEKLEQWRCEKP

Ligand information

• Ligand ID: CA
• InChI: InChI=1S/Ca/q+2
• InChIKey: BHPQYMZQTOCNFJ-UHFFFAOYSA-N
• SMILES:
  CACTVS 3.341: [Ca++]
  ACDLabs 10.04
  OpenEye OEToolkits 1.5.0: [Ca+2]
• Formula: Ca
• Name: CALCIUM ION
• DrugBank: DB14577
• PDB chain: 1nwg Chain A Residue 124

Receptor-Ligand Complex Structure

Structure summary

• PDB: 1nwg ALPHA-LACTALBUMIN (LA) STIMULATES MILK BETA-1,4-GALACTOSYLTRANSFERASE I (BETA 4GAL-T1) TO TRANSFER GLUCOSE FROM UDP-GLUCOSE TO N-ACETYLGLUCOSAMINE. CRYSTAL STRUCTURE OF BETA 4GAL-T1 X LA COMPLEX WITH UDP-GLC.
• Resolution: 2.32 Å
• Binding residue (original residue number in PDB): K79 D82 E84 D87 D88
• Binding residue (residue number reindexed from 1): K79 D82 E84 D87 D88
• Annotation score: 1

Enzymatic activity

• Catalytic site (original residue number in PDB): T33 N45 S47 E49 S56
• Catalytic site (residue number reindexed from 1): T33 N45 S47 E49 S56

Gene Ontology

Molecular Function

• GO:0004461 lactose synthase activity
• GO:0005509 calcium ion binding
• GO:0005515 protein binding
• GO:0046872 metal ion binding

Biological Process

• GO:0005989 lactose biosynthetic process

Cellular Component

• GO:0005576 extracellular region
• GO:0032991 protein-containing complex

External links

• PDB: RCSB:1nwg, PDBe:1nwg, PDBj:1nwg
• PDBsum: 1nwg
• PubMed: 11485999
• UniProt: P29752|LALBA_MOUSE Alpha-lactalbumin (Gene Name=Lalba)