Structure of PDB 1nph Chain A Binding Site BS01

Receptor Information
>1nph Chain A (length=323) Species: 10090 (Mus musculus) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
DDGTGQKQIWRIEGSNKVPVDPATYGQFYGGDSYIILYNYGQIIYNWQGA
QSTQDEVAASAILTAQLDEELGGTPVQSRVVQGKEPAHLMSLFGGKPMII
YKGGTSRDGGQTAPASIRLFQVRASSSGATRAVEVMPKSGALNSNDAFVL
KTPSAAYLWVGAGASEAEKTAAQELLKVLRSQHVQVEEGSEPDGFWEALG
GKTSYRTSPRLKDKKMDAHPPRLFACSNRIGRFVIEEVPGELMQEDLATD
DVMLLDTWDQVFVWVGKDSQEEEKTEALTSAKRYIETDPANRDRRTPITV
VRQGFEPPSFVGWFLGWDNNYWS
Ligand information
Ligand IDCA
InChIInChI=1S/Ca/q+2
InChIKeyBHPQYMZQTOCNFJ-UHFFFAOYSA-N
SMILES
SoftwareSMILES
CACTVS 3.341[Ca++]
ACDLabs 10.04
OpenEye OEToolkits 1.5.0		[Ca+2]
FormulaCa
NameCALCIUM ION
ChEMBL
DrugBankDB14577
ZINC
PDB chain1nph Chain A Residue 744 [Download ligand structure] [Download structure with residue number starting from 1] [View ligand structure]
Receptor-Ligand Complex Structure
Global viewLocal viewStructure summary

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PDB1nph Gelsolin Domains 4-6 in Active, Actin-Free Conformation Identifies Sites of Regulatory Calcium Ions
Resolution3.0 Å
Binding residue
(original residue number in PDB)		N564 D565 E587
Binding residue
(residue number reindexed from 1)		N145 D146 E168
Annotation score4
Enzymatic activity
Enzyme Commision number ?
Gene Ontology
Molecular Function
GO:0051015 actin filament binding

View graph for
Molecular Function
External links
PDB RCSB:1nph, PDBe:1nph, PDBj:1nph
PDBsum1nph
PubMed12742020
UniProtP13020|GELS_MOUSE Gelsolin (Gene Name=Gsn)

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