Structure of PDB 1nkh Chain A Binding Site BS01

Receptor Information

>1nkh Chain A (length=123) Species: 10090 (Mus musculus)

TELTKCKVSHAIKDIDGYQGISLLEWACVLFHTSGYDTQAVVNDNGSTEY
GLFQISDRFWCKSSEFPESENICGISCDKLLDDELDDDIACAKKILAIKG
IDYWKAYKPMCSEKLEQWRCEKP

Ligand information

• Ligand ID: CA
• InChI: InChI=1S/Ca/q+2
• InChIKey: BHPQYMZQTOCNFJ-UHFFFAOYSA-N
• SMILES:
  CACTVS 3.341: [Ca++]
  ACDLabs 10.04
  OpenEye OEToolkits 1.5.0: [Ca+2]
• Formula: Ca
• Name: CALCIUM ION
• DrugBank: DB14577
• PDB chain: 1nkh Chain A Residue 805

Receptor-Ligand Complex Structure

Structure summary

• PDB: 1nkh Crystal structure of lactose synthase reveals a large conformational change in its catalytic component, the beta-1,4-galactosyltransferase
• Resolution: 2.0 Å
• Binding residue (original residue number in PDB): K79 D82 E84 D87 D88
• Binding residue (residue number reindexed from 1): K79 D82 E84 D87 D88
• Annotation score: 1

Enzymatic activity

• Catalytic site (original residue number in PDB): T33 N45 S47 E49 S56
• Catalytic site (residue number reindexed from 1): T33 N45 S47 E49 S56

Gene Ontology

Molecular Function

• GO:0004461 lactose synthase activity
• GO:0005509 calcium ion binding
• GO:0005515 protein binding
• GO:0046872 metal ion binding

Biological Process

• GO:0005989 lactose biosynthetic process

Cellular Component

• GO:0005576 extracellular region
• GO:0032991 protein-containing complex

External links

• PDB: RCSB:1nkh, PDBe:1nkh, PDBj:1nkh
• PDBsum: 1nkh
• PubMed: 11419947
• UniProt: P29752|LALBA_MOUSE Alpha-lactalbumin (Gene Name=Lalba)