Structure of PDB 1n7d Chain A Binding Site BS01

Receptor Information
>1n7d Chain A (length=639) Species: 9606 (Homo sapiens) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
SVTCKSGDFSCGGNRCIPQFWRCDGQVDCNGSDEQGCPPKTCSQDEFRCH
DGRQFVCDSDRDCLDGSDEASCPVLTCGPASFQCNSSTCIPQLWACDNDP
DCEDGSDEWPQRCRGLYVFQGDSSPCSAFEFHCLSGECIHSSWRCDGGPD
CKDKSDEENCAVATCRPDEFQCSDGNCIHGSRQCDREYDCKDMSDEVGCV
NVTLCEGPNKFKCHSGECITLDKVCNMARDCRDWSDEPIKECGTNECLDN
NGGCSHVCNDLKIGYECLCPDGFQLVAQRRCEDIDECQDPDTCSQLCVNL
EGGYKCQCEEGFQLDPHTKACKAVGSIAYLFFTNRHERKMTLDRSEYTSL
IPNLRNVVALDTEVASNRIYWSDLSQRMICSTQLDRAHGSSYDTVISRDI
PDGLAVDWIHSNIYWTDSVLGTVSVADTKGVKRKTLFREQGSKPRAIVVD
PVHGFMYWTDWGTPAKIKKGGLNGVDIYSLVTENIQWPNGITLDLLSGRL
YWVDSKLHSISSIDVNGGNRKTILEDEKRLAHPFSLAVFEDKVFWTDIIN
EAIFSANRLTGSDVNLLAENLLSPEDMVLFHQLTQPRGVNWCERTTLSNG
GCQYLCLPAPQINPHSPKFTCACPDGMLLARDMRSCLTE
Ligand information
Ligand IDCA
InChIInChI=1S/Ca/q+2
InChIKeyBHPQYMZQTOCNFJ-UHFFFAOYSA-N
SMILES
SoftwareSMILES
CACTVS 3.341[Ca++]
ACDLabs 10.04
OpenEye OEToolkits 1.5.0		[Ca+2]
FormulaCa
NameCALCIUM ION
ChEMBL
DrugBankDB14577
ZINC
PDB chain1n7d Chain A Residue 1001 [Download ligand structure] [Download structure with residue number starting from 1] [View ligand structure]
Receptor-Ligand Complex Structure
Global viewLocal viewStructure summary

[Spin on] [Spin off] [Reset]
[High quality] [Low quality]
[White background] [Black background]
[Spin on] [Spin off] [Reset]
[High quality] [Low quality]
[White background] [Black background]
PDB1n7d Structure of the LDL receptor extracellular domain at endosomal pH
Resolution3.7 Å
Binding residue
(original residue number in PDB)		T294 N295 E296 D310 L311 K312 I313 Y315
Binding residue
(residue number reindexed from 1)		T244 N245 E246 D260 L261 K262 I263 Y265
Annotation score4
Enzymatic activity
Enzyme Commision number ?
Gene Ontology
Molecular Function
GO:0005509 calcium ion binding

View graph for
Molecular Function
External links
PDB RCSB:1n7d, PDBe:1n7d, PDBj:1n7d
PDBsum1n7d
PubMed12459547
UniProtP01130|LDLR_HUMAN Low-density lipoprotein receptor (Gene Name=LDLR)

[Back to BioLiP]