Structure of PDB 1n4m Chain A Binding Site BS01

Receptor Information
>1n4m Chain A (length=345) Species: 9606 (Homo sapiens) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
NTIQQLMMILNSASDQPSENLISYFNNCTVNPKESILKRVKDIGYIFKEK
FAKAVGAGCVAIGSQRYKLGVRLYYRVMESMLKSEEERLSIQNFSKLLND
NIFHMSLLACALEVVMATYSRSTSQNLDSGTDLSFPWILNVLNLKAFDFY
KVIESFIKAEGNLTREMIKHLERCEHRIMESLAWLSDSPLFDLIKQSKTR
EGKSTSLSLFYKKVYRLAYLRLNTLCERLLSEHPELEHIIWTLFQHTLQN
EYELMRDRHLDQIMMCSMYGICKVKNIDLKFKIIVTAYKDLPHAVQETFK
RVLIKEEEYDSIIVFYNSVFMQRLKTNILQYASTRPPTLSPIPHI
Ligand information
Receptor-Ligand Complex Structure
Global viewLocal viewStructure summary

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PDB1n4m Structural basis for the recognition of the E2F transactivation domain by the retinoblastoma tumor suppressor
Resolution2.2 Å
Binding residue
(original residue number in PDB)		E464 R467 K475 D479 F482 K530 E533 S534 K548 E551 E554 H555 L649 K652 K653 R656 I785
Binding residue
(residue number reindexed from 1)		E85 R88 K96 D100 F103 K151 E154 S155 K169 E172 E175 H176 L209 K212 K213 R216 I345
Enzymatic activity
Enzyme Commision number ?
Gene Ontology
Biological Process
GO:0006357 regulation of transcription by RNA polymerase II
GO:0051726 regulation of cell cycle
Cellular Component
GO:0005634 nucleus

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Biological Process
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Cellular Component
External links
PDB RCSB:1n4m, PDBe:1n4m, PDBj:1n4m
PDBsum1n4m
PubMed12502741
UniProtP06400|RB_HUMAN Retinoblastoma-associated protein (Gene Name=RB1)

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