Structure of PDB 1mtl Chain A Binding Site BS01

Receptor Information
>1mtl Chain A (length=157) Species: 562 (Escherichia coli) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
VEDILAPGLRVVFCGINPGLSSAGTGFPFAHPANRFWKVIYQAGFTDRQL
KPQEAQHLLDYRCGVTKLVANEVSKQELHAGGRKLIEKIEDYQPQALAIL
GKQAYEQGFSQRGAQWGKQTLTIGSTQIWVLPNPSGLSRVSLEKLVEAYR
ELDQALV
Ligand information
Receptor-Ligand Complex Structure
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PDB1mtl Structure of a DNA base-excision product resembling a cisplatin inter-strand adduct.
Resolution2.8 Å
Binding residue
(original residue number in PDB)		I17 L21 N78 G108 Q110 W123 P139 N140
Binding residue
(residue number reindexed from 1)		I16 L20 N71 G101 Q103 W116 P132 N133
Enzymatic activity
Catalytic site (original residue number in PDB) N18 P29
Catalytic site (residue number reindexed from 1) N17 P28
Enzyme Commision number 3.2.2.28: double-stranded uracil-DNA glycosylase.
Gene Ontology
Molecular Function
GO:0000700 mismatch base pair DNA N-glycosylase activity
GO:0003677 DNA binding
GO:0004844 uracil DNA N-glycosylase activity
GO:0008263 pyrimidine-specific mismatch base pair DNA N-glycosylase activity
GO:0016787 hydrolase activity
GO:0043739 G/U mismatch-specific uracil-DNA glycosylase activity
Biological Process
GO:0006281 DNA repair
GO:0006285 base-excision repair, AP site formation
Cellular Component
GO:0005737 cytoplasm

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Molecular Function
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Biological Process
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Cellular Component
External links
PDB RCSB:1mtl, PDBe:1mtl, PDBj:1mtl
PDBsum1mtl
PubMed9699633
UniProtP0A9H1|MUG_ECOLI G/U mismatch-specific DNA glycosylase (Gene Name=mug)

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