Structure of PDB 1mq0 Chain A Binding Site BS01

Receptor Information
>1mq0 Chain A (length=130) Species: 9606 (Homo sapiens) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
ECVQQLLVCSQEAKQSAYCPYSHFPVGAALLTQEGRIFKGCNIENACYPL
GICAERTAIQKAVSEGYKDFRAIAIASDMQDDFISPCGACRQVMREFGTN
WPVYMTKPDGTYIVMTVQELLPSSFGPEDL
Ligand information
Ligand IDZN
InChIInChI=1S/Zn/q+2
InChIKeyPTFCDOFLOPIGGS-UHFFFAOYSA-N
SMILES
SoftwareSMILES
CACTVS 3.341[Zn++]
ACDLabs 10.04
OpenEye OEToolkits 1.5.0		[Zn+2]
FormulaZn
NameZINC ION
ChEMBLCHEMBL1236970
DrugBankDB14532
ZINC
PDB chain1mq0 Chain A Residue 147 [Download ligand structure] [Download structure with residue number starting from 1] [View ligand structure]
Receptor-Ligand Complex Structure
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PDB1mq0 Structure of human cytidine deaminase bound to a potent inhibitor
Resolution2.4 Å
Binding residue
(original residue number in PDB)		C65 C99 C102
Binding residue
(residue number reindexed from 1)		C53 C87 C90
Annotation score1
Enzymatic activity
Enzyme Commision number 3.5.4.5: cytidine deaminase.
Gene Ontology
Molecular Function
GO:0001882 nucleoside binding
GO:0003824 catalytic activity
GO:0004126 cytidine deaminase activity
GO:0005515 protein binding
GO:0008270 zinc ion binding
GO:0016787 hydrolase activity
GO:0042802 identical protein binding
GO:0042803 protein homodimerization activity
GO:0046872 metal ion binding
Biological Process
GO:0007166 cell surface receptor signaling pathway
GO:0008655 pyrimidine-containing compound salvage
GO:0009972 cytidine deamination
GO:0019858 cytosine metabolic process
GO:0030308 negative regulation of cell growth
GO:0044206 UMP salvage
GO:0045980 negative regulation of nucleotide metabolic process
GO:0046898 response to cycloheximide
GO:0055086 nucleobase-containing small molecule metabolic process
GO:0071217 cellular response to external biotic stimulus
GO:0072527 pyrimidine-containing compound metabolic process
GO:1901135 carbohydrate derivative metabolic process
Cellular Component
GO:0005576 extracellular region
GO:0005737 cytoplasm
GO:0005829 cytosol
GO:0034774 secretory granule lumen
GO:1904724 tertiary granule lumen
GO:1904813 ficolin-1-rich granule lumen

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Molecular Function
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Biological Process
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Cellular Component
External links
PDB RCSB:1mq0, PDBe:1mq0, PDBj:1mq0
PDBsum1mq0
PubMed15689149
UniProtP32320|CDD_HUMAN Cytidine deaminase (Gene Name=CDA)

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