Structure of PDB 1moz Chain A Binding Site BS01

Receptor Information
>1moz Chain A (length=178) Species: 4932 (Saccharomyces cerevisiae) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
GNIFSSMFDKLWGSNKELRILILGLDGAGKTTILYRLQIGEVVTTKPTIG
FNVETLSYKNLKLNVWDLGIRPYWRCYYADTAAVIFVVDSTDKDRMSTAS
KELHLMLQEEELQDAALLVFANKQDQPGALSASEVSKELNLVELKDRSWS
IVASSAIKGEGITEGLDWLIDVIKEEQL
Ligand information
Ligand IDGDP
InChIInChI=1S/C10H15N5O11P2/c11-10-13-7-4(8(18)14-10)12-2-15(7)9-6(17)5(16)3(25-9)1-24-28(22,23)26-27(19,20)21/h2-3,5-6,9,16-17H,1H2,(H,22,23)(H2,19,20,21)(H3,11,13,14,18)/t3-,5-,6-,9-/m1/s1
InChIKeyQGWNDRXFNXRZMB-UUOKFMHZSA-N
SMILES
SoftwareSMILES
OpenEye OEToolkits 1.7.6c1nc2c(n1C3C(C(C(O3)COP(=O)(O)OP(=O)(O)O)O)O)N=C(NC2=O)N
CACTVS 3.385NC1=Nc2n(cnc2C(=O)N1)[C@@H]3O[C@H](CO[P](O)(=O)O[P](O)(O)=O)[C@@H](O)[C@H]3O
CACTVS 3.385NC1=Nc2n(cnc2C(=O)N1)[CH]3O[CH](CO[P](O)(=O)O[P](O)(O)=O)[CH](O)[CH]3O
ACDLabs 12.01O=P(O)(O)OP(=O)(O)OCC3OC(n2cnc1c2N=C(N)NC1=O)C(O)C3O
OpenEye OEToolkits 1.7.6c1nc2c(n1[C@H]3[C@@H]([C@@H]([C@H](O3)CO[P@](=O)(O)OP(=O)(O)O)O)O)N=C(NC2=O)N
FormulaC10 H15 N5 O11 P2
NameGUANOSINE-5'-DIPHOSPHATE
ChEMBLCHEMBL384759
DrugBankDB04315
ZINCZINC000008215481
PDB chain1moz Chain A Residue 184 [Download ligand structure] [Download structure with residue number starting from 1] [View ligand structure]
Receptor-Ligand Complex Structure
Global viewLocal viewStructure summary

[Spin on] [Spin off] [Reset]
[High quality] [Low quality]
[White background] [Black background]
[Spin on] [Spin off] [Reset]
[High quality] [Low quality]
[White background] [Black background]
PDB1moz Structures of Yeast ARF2 and ARL1: DISTINCT ROLES FOR THE N TERMINUS IN THE STRUCTURE AND FUNCTION OF ARF FAMILY GTPases
Resolution3.17 Å
Binding residue
(original residue number in PDB)		G28 A29 G30 K31 T32 T33 N127 K128 D130 S160 I162
Binding residue
(residue number reindexed from 1)		G27 A28 G29 K30 T31 T32 N122 K123 D125 S155 I157
Annotation score4
Enzymatic activity
Enzyme Commision number ?
Gene Ontology
Molecular Function
GO:0003924 GTPase activity
GO:0005515 protein binding
GO:0005525 GTP binding
GO:0016787 hydrolase activity
Biological Process
GO:0006623 protein targeting to vacuole
GO:0006886 intracellular protein transport
GO:0006897 endocytosis
GO:0006995 cellular response to nitrogen starvation
GO:0015031 protein transport
GO:0016192 vesicle-mediated transport
GO:0016236 macroautophagy
GO:0031503 protein-containing complex localization
GO:0032258 cytoplasm to vacuole targeting by the Cvt pathway
GO:0034067 protein localization to Golgi apparatus
GO:0034497 protein localization to phagophore assembly site
GO:0034605 cellular response to heat
GO:0034976 response to endoplasmic reticulum stress
GO:0043001 Golgi to plasma membrane protein transport
GO:0098629 trans-Golgi network membrane organization
Cellular Component
GO:0000407 phagophore assembly site
GO:0005794 Golgi apparatus
GO:0005802 trans-Golgi network
GO:0005829 cytosol
GO:0010008 endosome membrane

View graph for
Molecular Function
View graph for
Biological Process
View graph for
Cellular Component
External links
PDB RCSB:1moz, PDBe:1moz, PDBj:1moz
PDBsum1moz
PubMed11535602
UniProtP38116|ARL1_YEAST ADP-ribosylation factor-like protein 1 (Gene Name=ARL1)

[Back to BioLiP]