Structure of PDB 1mhd Chain A Binding Site BS01

Receptor Information
>1mhd Chain A (length=123) Species: 9606 (Homo sapiens) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
PIVKRLLGWKKGEQNGQEEKWCEKAVKSLVKKLKKTGQLDELEKAITTQN
VNTKCITIPRSLDGRLQVSHRKGLPHVIYCRLWRWPDLHSHHELRAMELC
EFAFNMKKDEVCVNPYHYQRVET
Ligand information
Receptor-Ligand Complex Structure
Global viewLocal viewStructure summary

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PDB1mhd Crystal structure of a Smad MH1 domain bound to DNA: insights on DNA binding in TGF-beta signaling.
Resolution2.8 Å
Binding residue
(original residue number in PDB)		S70 L71 Q76 K81
Binding residue
(residue number reindexed from 1)		S61 L62 Q67 K72
Binding affinityPDBbind-CN: Kd=114nM
Enzymatic activity
Enzyme Commision number ?
Gene Ontology
Biological Process
GO:0006355 regulation of DNA-templated transcription
Cellular Component
GO:0005667 transcription regulator complex

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Biological Process
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Cellular Component
External links
PDB RCSB:1mhd, PDBe:1mhd, PDBj:1mhd
PDBsum1mhd
PubMed9741623
UniProtP84022|SMAD3_HUMAN Mothers against decapentaplegic homolog 3 (Gene Name=SMAD3)

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