Structure of PDB 1m8y Chain A Binding Site BS01

Receptor Information
>1m8y Chain A (length=341) Species: 9606 (Homo sapiens) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
GRSRLLEDFRNNRYPNLQLREIAGHIMEFSQDQHGSRFIQLKLERATPAE
RQLVFNEILQAAYQLMVDVFGNYVIQKFFEFGSLEQKLALAERIRGHVLS
LALQMYGCRVIQKALEFIPSDQQNEMVRELDGHVLKCVKDQNGNHVVQKC
IECVQPQSLQFIIDAFKGQVFALSTHPYGCRVIQRILEHCLPDQTLPILE
ELHQHTEQLVQDQYGNYVIQHVLEHGRPEDKSKIVAEIRGNVLVLSQHKF
ASNVVEKCVTHASRTERAVLIDEVCTMNDGPHSALYTMMKDQYANYVVQK
MIDVAEPGQRKIVMHKIRPHIATLRKYTYGKHILAKLEKYY
Ligand information
Receptor-Ligand Complex Structure
Global viewLocal viewStructure summary

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PDB1m8y MODULAR RECOGNITION OF RNA BY A HUMAN PUMILIO-HOMOLOGY DOMAIN
Resolution2.6 Å
Binding residue
(original residue number in PDB)		Q860 R864 Q867 F897 N899 Y900 Y933 R936 Q939 H972 C1007 R1008 Q1011 N1043 Y1044 F1077 N1080 E1083 N1122 Y1123 Y1156 H1159
Binding residue
(residue number reindexed from 1)		Q33 R37 Q40 F70 N72 Y73 Y106 R109 Q112 H145 C180 R181 Q184 N216 Y217 F250 N253 E256 N295 Y296 Y329 H332
Binding affinityPDBbind-CN: Kd=160nM
Enzymatic activity
Enzyme Commision number ?
Gene Ontology

View graph for
Molecular Function
External links
PDB RCSB:1m8y, PDBe:1m8y, PDBj:1m8y
PDBsum1m8y
PubMed12202039
UniProtQ14671|PUM1_HUMAN Pumilio homolog 1 (Gene Name=PUM1)

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