Structure of PDB 1m8w Chain A Binding Site BS01

Receptor Information
>1m8w Chain A (length=340) Species: 9606 (Homo sapiens) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
GRSRLLEDFRNNRYPNLQLREIAGHIMEFSQDQHGSRFIQLKLERATPAE
RQLVFNEILQAAYQLMVDVFGNYVIQKFFEFGSLEQKLALAERIRGHVLS
LALQMYGCRVIQKALEFIPSDQQNEMVRELDGHVLKCVKDQNGNHVVQKC
IECVQPQSLQFIIDAFKGQVFALSTHPYGCRVIQRILEHCLPDQTLPILE
ELHQHTEQLVQDQYGNYVIQHVLEHGRPEDKSKIVAEIRGNVLVLSQHKF
ASNVVEKCVTHASRTERAVLIDEVCTMNDGPHSALYTMMKDQYANYVVQK
MIDVAEPGQRKIVMHKIRPHIATLRKYTYGKHILAKLEKY
Ligand information
Receptor-Ligand Complex Structure
Global viewLocal viewStructure summary

[Spin on] [Spin off] [Reset]
[High quality] [Low quality]
[White background] [Black background]
[Spin on] [Spin off] [Reset]
[High quality] [Low quality]
[White background] [Black background]
PDB1m8w MODULAR RECOGNITION OF RNA BY A HUMAN PUMILIO-HOMOLOGY DOMAIN
Resolution2.2 Å
Binding residue
(original residue number in PDB)		N899 Y900 R936 Q939 H972 Q975 C1007 R1008 Q1011 N1043 Y1044 Q1047 F1077 S1079 N1080 E1083 Y1120 N1122 Y1123 Q1126 Y1156 H1159
Binding residue
(residue number reindexed from 1)		N72 Y73 R109 Q112 H145 Q148 C180 R181 Q184 N216 Y217 Q220 F250 S252 N253 E256 Y293 N295 Y296 Q299 Y329 H332
Binding affinityPDBbind-CN: Kd=500nM
Enzymatic activity
Enzyme Commision number ?
Gene Ontology

View graph for
Molecular Function
External links
PDB RCSB:1m8w, PDBe:1m8w, PDBj:1m8w
PDBsum1m8w
PubMed12202039
UniProtQ14671|PUM1_HUMAN Pumilio homolog 1 (Gene Name=PUM1)

[Back to BioLiP]