Structure of PDB 1m6p Chain A Binding Site BS01

Receptor Information
>1m6p Chain A (length=146) Species: 9913 (Bos taurus) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
EKTCDLVGEKGKESEKELALLKRLTPLFQKSFESTMYSYVFRVCREAGQH
SSGAGLVQIQKSNGKETVVGRFNETQIFQGSNWIMLIYKGGDEYDNHCGR
EQRRAVVMISCNRHTLADNFNPVSEERGKVQDCFYLFEMDSSLACS
Ligand information
Ligand IDMN
InChIInChI=1S/Mn/q+2
InChIKeyWAEMQWOKJMHJLA-UHFFFAOYSA-N
SMILES
SoftwareSMILES
ACDLabs 10.04
OpenEye OEToolkits 1.5.0		[Mn+2]
CACTVS 3.341[Mn++]
FormulaMn
NameMANGANESE (II) ION
ChEMBL
DrugBankDB06757
ZINC
PDB chain1m6p Chain A Residue 199 [Download ligand structure] [Download structure with residue number starting from 1] [View ligand structure]
Receptor-Ligand Complex Structure
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PDB1m6p Molecular basis of lysosomal enzyme recognition: three-dimensional structure of the cation-dependent mannose 6-phosphate receptor.
Resolution1.8 Å
Binding residue
(original residue number in PDB)		D103 R111
Binding residue
(residue number reindexed from 1)		D95 R103
Annotation score4
Enzymatic activity
Enzyme Commision number ?
Gene Ontology
Molecular Function
GO:0019904 protein domain specific binding
Biological Process
GO:0006622 protein targeting to lysosome
Cellular Component
GO:0005768 endosome
GO:0005794 Golgi apparatus

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Biological Process
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Cellular Component
External links
PDB RCSB:1m6p, PDBe:1m6p, PDBj:1m6p
PDBsum1m6p
PubMed9604938
UniProtP11456|MPRD_BOVIN Cation-dependent mannose-6-phosphate receptor (Gene Name=M6PR)

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