Structure of PDB 1m4m Chain A Binding Site BS01

PDB	1m4m CRYSTAL STRUCTURE AND MUTAGENIC ANALYSIS OF THE INHIBITOR-OF-APOPTOSIS PROTEIN SURVIVIN
Resolution	2.8 Å
Binding residue (original residue number in PDB)	E76 H80
Binding residue (residue number reindexed from 1)	E70 H74
Annotation score	4

Enzymatic activity

Enzyme Commision number

Gene Ontology

	Molecular Function
GO:0004869	cysteine-type endopeptidase inhibitor activity
GO:0005515	protein binding
GO:0008017	microtubule binding
GO:0008270	zinc ion binding
GO:0015631	tubulin binding
GO:0042803	protein homodimerization activity
GO:0043027	cysteine-type endopeptidase inhibitor activity involved in apoptotic process
GO:0046872	metal ion binding

	Biological Process
GO:0000086	G2/M transition of mitotic cell cycle
GO:0000226	microtubule cytoskeleton organization
GO:0000278	mitotic cell cycle
GO:0000281	mitotic cytokinesis
GO:0006468	protein phosphorylation
GO:0006915	apoptotic process
GO:0007052	mitotic spindle organization
GO:0007059	chromosome segregation
GO:0007094	mitotic spindle assembly checkpoint signaling
GO:0007127	meiosis I
GO:0007346	regulation of mitotic cell cycle
GO:0010466	negative regulation of peptidase activity
GO:0031503	protein-containing complex localization
GO:0031536	positive regulation of exit from mitosis
GO:0043066	negative regulation of apoptotic process
GO:0043154	negative regulation of cysteine-type endopeptidase activity involved in apoptotic process
GO:0043524	negative regulation of neuron apoptotic process
GO:0045892	negative regulation of DNA-templated transcription
GO:0045931	positive regulation of mitotic cell cycle
GO:0051256	mitotic spindle midzone assembly
GO:0051301	cell division
GO:0051303	establishment of chromosome localization
GO:0061178	regulation of insulin secretion involved in cellular response to glucose stimulus
GO:0061469	regulation of type B pancreatic cell proliferation
GO:0090267	positive regulation of mitotic cell cycle spindle assembly checkpoint
GO:1901970	positive regulation of mitotic sister chromatid separation
GO:1902425	positive regulation of attachment of mitotic spindle microtubules to kinetochore
GO:1903490	positive regulation of mitotic cytokinesis

	Cellular Component
GO:0000775	chromosome, centromeric region
GO:0000776	kinetochore
GO:0005634	nucleus
GO:0005694	chromosome
GO:0005737	cytoplasm
GO:0005814	centriole
GO:0005819	spindle
GO:0005829	cytosol
GO:0005856	cytoskeleton
GO:0005874	microtubule
GO:0005876	spindle microtubule
GO:0005881	cytoplasmic microtubule
GO:0015630	microtubule cytoskeleton
GO:0030496	midbody
GO:0031021	interphase microtubule organizing center
GO:0032133	chromosome passenger complex
GO:1990713	survivin complex

External links

PDB	RCSB:1m4m, PDBe:1m4m, PDBj:1m4m
PDBsum	1m4m
PubMed	10949038
UniProt	O70201\|BIRC5_MOUSE Baculoviral IAP repeat-containing protein 5 (Gene Name=Birc5)