Structure of PDB 1m43 Chain A Binding Site BS01

Receptor Information
>1m43 Chain A (length=331) Species: 5833 (Plasmodium falciparum) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
LGSSNDNIELVDFQNIMFYGDAEVGDNQQPFTFILDTGSANLWVPSVKCT
TAGCLTKHLYDSSKSRTYEKDGTKVEMNYVSGTVSGFFSKDLVTVGNLSL
PYKFIEVIDTNGFEPTYTASTFDGILGLGWKDLSIGSVDPIVVELKNQNK
IENALFTFYLPVHDKHTGFLTIGGIEERFYEGPLTYEKLNHDLYWQITLD
AHVGNISLEKANCIVDSGTSAITVPTDFLNKMLQNLDVIKVPFLPFYVTL
CNNSKLPTFEFTSENGKYTLEPEYYLQHIEDVGPGLCMLNIIGLDFPVPT
FILGDPFMRKYFTVFDYDNHSVGIALAKKNL
Ligand information
>1m43 Chain C (length=6) Species: 285516 (Streptomyces argenteolus subsp. toyonakensis) [Search peptide sequence] [Download ligand structure] [Download structure with residue number starting from 1] [View ligand structure]
VVVLAL
Receptor-Ligand Complex Structure
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PDB1m43 Novel uncomplexed and complex structures of PM II, an aspartic protease from P. falciparum
Resolution2.4 Å
Binding residue
(original residue number in PDB)		M15 I32 D34 G36 N76 Y77 V78 S79 Y192 D214 G216 T217 S218
Binding residue
(residue number reindexed from 1)		M17 I34 D36 G38 N78 Y79 V80 S81 Y194 D216 G218 T219 S220
Enzymatic activity
Catalytic site (original residue number in PDB) D34 S37 N39 W41 Y77 D214 T217
Catalytic site (residue number reindexed from 1) D36 S39 N41 W43 Y79 D216 T219
Enzyme Commision number 3.4.23.39: plasmepsin II.
Gene Ontology
Molecular Function
GO:0004190 aspartic-type endopeptidase activity
Biological Process
GO:0006508 proteolysis

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Molecular Function
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Biological Process
External links
PDB RCSB:1m43, PDBe:1m43, PDBj:1m43
PDBsum1m43
PubMed
UniProtP46925|PLM2_PLAFX Plasmepsin II (Gene Name=PMII)

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