Structure of PDB 1m0w Chain A Binding Site BS01

Receptor Information

>1m0w Chain A (length=481) Species: 4932 (Saccharomyces cerevisiae)

PSKDQLNELIQEVNQWAITNGLSMYPPKFEENPSNASVSPVTIYPTPIPR
KCFDEAVQIQPVFNELYARITQDMAQPDSYLHKTTEALALSDSEFTGKLW
SLYLATLKSAQYKKQNFRLGIFRSDYLIDKKKGTEQIKQVEFNTVSVSFA
GLSEKVDRLHSYLNRANKYDPKGPIYNDQNMVISDSGYLLSKALAKAVES
YKSQQSDPIVAFIVQRNERNVFDQKVLELNLLEKFGTKSVRLTFDDVNDK
LFIDDKTGKLFIRDTEQEIAVVYYRTGYTTTDYTSEKDWEARLFLEKSFA
IKAPDLLTQLSGSKKIQQLLTDEGVLGKYISDAEKKSSLLKTFVKIYPLD
DTKLGREGKRLALSEPSKYVLKPQREGGGNNVYKENIPNFLKGIEERHWD
AYILMELIEPELNENNIILRDNKSYNEPIISELGIYGCVLFNDEQVLSNE
FSGSLLRSKFNTSNEGGVAAGFGCLDSIILY

Ligand information

• Ligand ID: MG
• InChI: InChI=1S/Mg/q+2
• InChIKey: JLVVSXFLKOJNIY-UHFFFAOYSA-N
• SMILES:
  ACDLabs 10.04
  OpenEye OEToolkits 1.5.0: [Mg+2]
  CACTVS 3.341: [Mg++]
• Formula: Mg
• Name: MAGNESIUM ION
• DrugBank: DB01378
• PDB chain: 1m0w Chain A Residue 503

Receptor-Ligand Complex Structure

Structure summary

• PDB: 1m0w Large Conformational Changes in the Catalytic Cycle of Glutathione Synthase
• Resolution: 1.8 Å
• Binding residue (original residue number in PDB): E146 E386
• Binding residue (residue number reindexed from 1): E141 E376
• Annotation score: 1

Enzymatic activity

• Enzyme Commision number: 6.3.2.3: glutathione synthase.

Gene Ontology

Molecular Function

• GO:0000287 magnesium ion binding
• GO:0004363 glutathione synthase activity
• GO:0005524 ATP binding
• GO:0016874 ligase activity
• GO:0042803 protein homodimerization activity
• GO:0043295 glutathione binding
• GO:0046872 metal ion binding

Biological Process

• GO:0006750 glutathione biosynthetic process

Cellular Component

• GO:0005737 cytoplasm
• GO:0005829 cytosol

External links

• PDB: RCSB:1m0w, PDBe:1m0w, PDBj:1m0w
• PDBsum: 1m0w
• PubMed: 12467574
• UniProt: Q08220|GSHB_YEAST Glutathione synthetase GSH2 (Gene Name=GSH2)