Structure of PDB 1lv0 Chain A Binding Site BS01

Receptor Information
>1lv0 Chain A (length=433) Species: 9913 (Bos taurus) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
HHMDEEYDVIVLGTGLTECILSGIMSVNGKKVLHMDRNPYYGGESSSITP
LEELYKRFQLLEGPPETMGRGRDWNVDLIPKFLMANGQLVKMLLYTEVTR
YLDFKVVEGSFVYKGGKIYKVPSTETEALASNLMGMFEKRRFRKFLVFVA
NFDENDPKTFEGVDPQNTSMRDVYRKFDLGQDVIDFTGHALALYRTDDYL
DQPCLETINRIKLYSESLARYGKSPYLYPLYGLGELPQGFARLSAIYGGT
YMLNKPVDDIIMENGKVVGVKSEGEVARCKQLICDPSYVPDRVRKAGQVI
RIICILSHPIKNTNDANSCQIIIPQNQVNRKSDIYVCMISYAHNVAAQGK
YIAIASTTVETTDPEKEVEPALELLEPIDQKFVAISDLYEPIDDGSESQV
FCSCSYDATTHFETTCNDIKDIYKRMAGSAFDF
Ligand information
Ligand IDGER
InChIInChI=1S/C20H34/c1-7-18(4)12-9-14-20(6)16-10-15-19(5)13-8-11-17(2)3/h7,11,14-15H,8-10,12-13,16H2,1-6H3/b18-7+,19-15+,20-14+
InChIKeyHSOYJGBJQAKCNA-CAIKYXSQSA-N
SMILES
SoftwareSMILES
ACDLabs 10.04C(=C/CCC(=C/C)/C)(\CC/C=C(/CC/C=C(\C)C)C)C
OpenEye OEToolkits 1.5.0C\C=C(/C)\CC\C=C(/C)\CC\C=C(/C)\CCC=C(C)C
CACTVS 3.341
OpenEye OEToolkits 1.5.0		CC=C(C)CCC=C(C)CCC=C(C)CCC=C(C)C
CACTVS 3.341C\C=C(/C)CC\C=C(/C)CC\C=C(/C)CCC=C(C)C
FormulaC20 H34
NameGERAN-8-YL GERAN
ChEMBL
DrugBank
ZINCZINC000014880577
PDB chain1lv0 Chain A Residue 1000 [Download ligand structure] [Download structure with residue number starting from 1] [View ligand structure]
Receptor-Ligand Complex Structure
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PDB1lv0 Geranylgeranyl switching regulates GDI-Rab GTPase recycling.
Resolution2.0 Å
Binding residue
(original residue number in PDB)		V25 Y93 D430
Binding residue
(residue number reindexed from 1)		V27 Y95 D432
Annotation score1
Enzymatic activity
Enzyme Commision number ?
Gene Ontology
Molecular Function
GO:0005092 GDP-dissociation inhibitor activity
GO:0005093 Rab GDP-dissociation inhibitor activity
GO:0005096 GTPase activator activity
Biological Process
GO:0007264 small GTPase-mediated signal transduction
GO:0015031 protein transport
GO:0016192 vesicle-mediated transport
GO:0032482 Rab protein signal transduction
GO:0050771 negative regulation of axonogenesis
GO:0090315 negative regulation of protein targeting to membrane
Cellular Component
GO:0005737 cytoplasm
GO:0005794 Golgi apparatus
GO:0005829 cytosol

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Molecular Function
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Biological Process
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Cellular Component
External links
PDB RCSB:1lv0, PDBe:1lv0, PDBj:1lv0
PDBsum1lv0
PubMed12623022
UniProtP21856|GDIA_BOVIN Rab GDP dissociation inhibitor alpha (Gene Name=GDI1)

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